摘要
目的运用中医传承辅助平台(V2.5)分析新型冠状病毒肺炎(新冠肺炎)治疗的用药规律和组方原则。方法收集2021年1月至3月河北中医学院第一附属医院医疗队支援河北省新冠定点医院期间收治且临床确诊为普通型新冠肺炎患者和无症状感染者的临床资料,包括性别、年龄、临床症状、中药用药频次和处方信息等,将信息资料录入中医传承辅助平台(V2.5),数据的挖掘与分析通过该软件的集成关联规则及复杂熵聚类等分析方法实现,包括对每味药物使用频次、药物归经和性味以及组方规律的分析,同时衍化出新处方。结果共纳入564例患者(即564张处方),涉及中药200味,其中普通型新冠肺炎357例,无症状感染207例。普通型新冠肺炎患者的女性比例较高,高发年龄段为51~70岁;无症状感染者性别则无明显差别,高发年龄段为1~20岁。大部分患者以头重、咳嗽为主要临床表现,其次为低热、咳痰,两种类型患者的主要舌苔和脉象相似。普通型新冠肺炎患者所用中药频次从高到低依次为甘草(326次)、茯苓(264次)、半夏(263次)、杏仁(236次)、黄芩(229次)、石膏(205次)、藿香(201次)、陈皮(194次)、麻黄(184次)、柴胡(163次),无症状感染者则为黄芩(174次)、甘草(142次)、神曲(137次)、藿香(127次)、半夏(114次)、柴胡(100次)、厚朴(91次)、苍术(89次)、赤芍(84次)、黄芪(83次)。两种类型患者用药均以温、寒、平药物为主,性味以辛、苦、甘为主,用药归经均以肺、脾、胃为主,高频药物组方均以化浊解毒药物为主。同时衍化出用于普通型新冠肺炎的新处方7张,用于无症状感染者的新处方4张。结论浊毒疫戾是新冠肺炎发生发展的基本病因,化浊解毒为基本治则;在此基础上,对于普通型新冠肺炎患者应同时兼顾解表、清热、化痰、止咳药等对症治疗,对于无症状感染者的治疗则应更侧重于扶正祛邪。
Objective To analyze the rules of medication and principles of formulas for the treatment of coronavirus disease 2019(COVID-19)using the traditional Chinese medicine inheritance support platform(V2.5).Methods The clinical data,including gender,age,clinical symptoms,frequency of traditional Chinese medicine medication and prescription information,of patients with COVID-19 and asymptomatic infection who were admitted to Hebei COVID-19 designated hospital supported by medical team of First Affiliated Hospital of Hebei University of Chinese Medicine from January to March 2021 were collected.The information data were input into the traditional Chinese medicine inheritance support platform(V2.5).The data mining and analysis were realized by the integrated association rules and complex entropy clustering analysis methods of the software,including the analysis of the frequency of each drug use,drug meridian,taste,and prescription rules,and the new prescriptions were developed.Results A total of 564 patients(564 prescriptions)were enrolled,involving 200 Chinese herbs,including 357 cases of common COVID-19 and 207 cases of asymptomatic infection.The proportion of women with common COVID-19 was high,and the high incidence age group was 51-70 years old.There was no significant difference in gender of asymptomatic infection,and the high incidence age group was 1-20 years old.The main clinical manifestations of most patients were head heavy and cough,followed by low fever and cough with sputum,the main tongue coating and pulse pattern were similar in both types of patients.The frequency of traditional Chinese medicine used in patients with common type of COVID-19 from high to low was liquorice root(326 times),indian bread(264 times),pinellia tuber(263 times),bitter apricot seed(236 times),baical skullcap root(229 times),gypsum(205 times),agastache rugosus(201 times),dried tangerine peel(194 times),ephedra(184 times),and Chinese thorowax root(163 times),while that used by asymptomatic infection were baical skullcap root(174 tim
作者
刘娇
李德辉
梅建强
武蕾
陈分乔
刘源
郎晓猛
袁国栋
赵亚伟
Liu Jiao;Li Dehui;Mei Jianqiang;Wu Lei;Chen Fenqiao;Liu Yuan;Lang Xiaomeng;Yuan Guodong;Zhao Yawei(Second Department of Tumor,First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,Hebei,China;Graduate School of Hebei University of Chinese Medicine,Shijiazhuang 050091,Hebei,China;Department of Emergency,First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,Hebei,China;Second Department of Respiratory,First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,Hebei,China;Department of Critical Care Medicine,First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,Hebei,China;First Department of Spleen and Stomach,First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,Hebei,China;First Department of Nephrology,First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,Hebei,China;Department of Encephalopathy,First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,Hebei,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2022年第5期454-458,共5页
Chinese Critical Care Medicine
基金
河北省自然科学基金(H2021423060)
国家中医药管理局梅建强全国名老中医药专家传承工作室(2022-75)。
关键词
新型冠状病毒肺炎
中医传承辅助平台
数据挖掘
用药规律
石家庄
Coronavirus disease 2019
Traditional Chinese medicine inheritance support platform
Data mining
Medication rule
Shijiazhuang
