摘要
目的研究小儿轮状病毒(RV)和诺如病毒(NV)性肠炎的血清PCT、IL-6、SAA水平的变化及临床特征,并分析二者鉴别要素。方法选取2019年11月至2021年01月昆明市儿童医院感染性疾病科收住院的水样腹泻、诊断病毒性肠炎的患儿作为研究对象。在入院24 h内采集粪便和收集静脉血,进行粪便轮状病毒、诺如病毒检测及血细胞、血清降钙素原(PCT)、白介素-6(IL-6)、血清淀粉样蛋白A(SAA)水平的测定,记录患儿的性别、年龄、24 h内最多的呕吐及腹泻次数、并发症、最高体温(maximum BT)、Vesikari评分等临床特征,采用多因素Logistic回归分析并通过ROC评估模型的准确性。结果143例患儿进入研究,其中RV76例,NV67例。RV组maximum BT,24 h内腹泻最多次数,Vesikari评分,中性粒细胞计数(NEUT)、SAA、体温>38℃病人数高于NV组,且差异有统计学意义(P<0.05);2组在性别、年龄、24 h呕吐最多次数、并发症、Vesikari评分≥11分人数、白细胞计数(WBC)、PCT、CRP、IL-6水平比较,差异无统计学意义(P>0.05)。多因素Logistic回归分析显示,maximum BT、NEUT、及SAA是鉴别二者的独立因素,运用ROC评估模型的准确性,其AUC 0.838(95%CI:0.770~0.907,P<0.001),最大约登指数(J=0.573),其敏感性为83.6%,特异性为73.7%。结论RV性肠炎相对NV来说,病情更危重,引起发热且体温>38℃的人数、24 h内腹泻次数更多。一个包含maximum BT、NEUT及SAA的模型可以协助儿科医生在未知病原体感染前进行鉴别。
Objective To investigate the changes in serum PCT,IL-6,SAA levels and clinical characteristics of pediatric rotavirus(RV)and norovirus(NV)enteritis,and to analyze the factors for distinguishing the two.Methods In a prospective observational study,we selected children with watery diarrhea and diagnosed viral enteritis who were admitted to the Department of Infectious Diseases of Kunming Children’s Hospital from November 2019 to January 2021 as the research objects.Stool and venous blood samples were collected within 24 hours after admission for detection of fecal rotavirus and norovirus and determination of blood cells,serum procalcitonin(PCT),interleukin-6(IL-6)and serum amyloid A(SAA).The gender,age,the most vomiting and diarrhea times within 24 h,complications,maximum BT,Vesikari score and other clinical characteristics of the children were analyzed by multivariate logistic regression and the accuracy of the model was assessed by ROC.Results 143 children were eligible,among which 76 were RV and 67 were NV.The maximum BT,the highest number of diarrhea within 24 hours,Vesikari score,neutrophil count(NEUT),SAA,and the number of patients with body temperature>38℃were significantly higher in the RV group than those in the NV group(P<0.05);There were no statistically significant differences in gender,age,the maximum number of vomiting at 24 h,complications,the number of people with Vesikari score≥11,white blood cell count(WBC),PCT,CRP,and IL-6 levels(P>0.05).Multivariate logistic regression analysis showed that maximum BT,NEUT,and SAA were independent factors that distinguished the two.ROC was used to assess the accuracy of the model,and its AUC was 0.838(95%CI:0.770-0.907,P<0.001),maximum approximate den index(J=0.573),sensitivity was 83.6%,specificity was 73.7%.Conclusion RV enteritis causes more patients with higher fever(>38℃),and there are more frequent diarrhea within 24 hours,which is more serious than NV enteritis.A model containing maximum BT,NEUT and SAA can assist pediatricians in differential diag
作者
鲁智英
王美芬
彭俊超
杜曾庆
罗云娇
马薇
LU Zhiying;WANG Meifen;PENG Junchao;DU Zengqing;LUO Yunjiao;MA Wei(Dept.of Infectious Diseases,Kunming Children’s Hospital,Yunnan Kunming 650028,China)
出处
《昆明医科大学学报》
CAS
2022年第8期138-144,共7页
Journal of Kunming Medical University
基金
昆明市卫生健康委员会卫生科研课题基金资助项目(2019-06-01-025)
昆明市“高层次人才”春城名医专项基金资助项目(N08901141)。
