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阴阳双补方治疗骨转移癌作用机制探讨

Study on the Mechanism of Yin Yang Shuangbu Formula in the Treatment of Bone Metastatic Carcinoma
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摘要 目的 从网络药理学角度分析阴阳双补方治疗恶性肿瘤骨转移的可能作用机制。方法 在中药数据库筛选阴阳双补方主要有效成分,并在Swiss Target Prediction数据库中检索其相应靶点,通过疾病数据库检索骨转移癌基因。通过韦恩分析映射出潜在治疗靶点,并在DAVID平台数据库中对其进行富集分析。结果筛选出150个潜在治疗靶点,其中关键靶点为EGFR、CASP3及STAT3等;富集分析发现阴阳双补方可能通过HIF-1、Rap1及VEGF等通路来发挥潜在抗恶性肿瘤骨转移治疗作用。结论 从网络药理学角度揭示了阴阳双补方治疗恶性肿瘤骨转移的复杂机制,对未来临床用药及课题组后期基础研究提供了一定参考价值。 Objective:To analyze the possible mechanism of Yin Yang Shuangbu Formula in treating malignant tumor bone metastasis from the perspective of network pharmacology. Methods:Traditional Chinese medicine databases were used to screen the main effective components of Yin Yang Shuangbu Formula. Swiss Target database was used to search the corresponding targets. Disease databases were used to search the genes of bone metastatic carcinoma. The potential therapeutic targets were mapped according to Venn analysis. Enrichment analysis was performed in DAVID platform database. Results:A total of 150 potential therapeutic targets were screened,of which the key targets were EGFR,CASP3 and STAT3. Through enrichment analysis,it was found that Yin Yang Shuangbu Formula might play a potential therapeutic role in anti-malignant tumor bone metastasis through HIF-1,Rap1,VEGF and other pathways. Conclusion:From the perspective of network pharmacology,this paper reveals the complex mechanism of Yin Yang Shuangbu Formula in treating malignant tumor bone metastasis,which provides a certain reference value for clinicians in the future and our team′s later basic research.
作者 杨梦霞 芦殿荣 朱世杰 周磊 Yang Mengxia;Lu Dianrong;Zhu Shijie;Zhou Lei(Wanting Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China)
出处 《中国中医急症》 2022年第7期1140-1143,1164,共5页 Journal of Emergency in Traditional Chinese Medicine
基金 国家自然科学基金面上项目(81973640) 中国中医科学院望京医院院级课题(WJYY2020-26)
关键词 恶性肿瘤转移 阴阳双补方 网络药理学 靶点 通路 Malignant tumor metastasis Bone Yin Yang Shuangbu Formula Network pharmacology Targets Pathways
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