摘要
目的 回顾性分析中西医结合治疗对肺癌患者生存预后的影响。方法 回顾性分析某医院2003年1月-2009年8月收治的951例中西医结合治疗肺癌的病例资料,通过单因素分析法(Kaplan-Meier)及Cox回归多因素分析,分析影响生存期的独立预后因素。结果 (1)951例中医药参与的治疗后,患者中位生存期:Ⅰa期45个月,Ⅰb期44个月,Ⅱa期39个月,Ⅱb期34个月,Ⅲa期19个月,Ⅲb期17个月,Ⅳ期14个月。(2)1~5年生存率:Ⅰ期:77%、66%、56%、51%、12%;Ⅱ期:67%、57%、49%、39%、18%;Ⅲ期:42%、26%、19%、13%、4%;Ⅳ期:31%、19%、14%、8%、2%。(3)单因素分析显示:性别、年龄、吸烟指数、临床分期、病理类型、辨证分型、治则、中药服用时长、手术、化疗是生存预后的影响因素(P<0.05);多因素分析显示:性别、年龄、临床分期、病理类型、治则、中药服用时长、手术、化疗是肺癌患者的独立预后因素(P<0.05)。结论 中西医结合治疗肺癌患者的预后影响因素较多,其中性别、年龄、临床分期、病理类型、治则、中药服用时长、手术、化疗是影响其预后的主要因素。
Objective To retrospectively analyze the effect of integrated traditional Chinese and Western medicine on the survival and prognosis of lung cancer patients.Methods The data of 951 cases of lung cancer treated with combination of Chinese and Western medicine in certain hospital from January 2003 to August 2009 were retrospectively analyzed.The independent prognostic factors affecting survival were analyzed by Kaplan-Meier and Cox regression.Results①After the treatment with Chinese medicine,the median survival time of 951 patients was 45 months in stageⅠa,44 months in stageⅠb,39 months in stageⅡa,34 months in stageⅡb,19 months in stageⅢa,17 months in stageⅢb and 14 months in stageⅣ.②1-5 year survival rate:stage I:77%,66%,56%,51%,12%;stageⅡ:67%,57%,49%,39%,18%;stage III:42%,26%,19%,13%,4%;stageⅣ:31%,19%,14%,8%,2%.③Univariate analysis showed that gender,age,smoking index,clinical stage,pathological type,syndrome differentiation,treatment principle,duration of traditional Chinese medicine,operation and chemotherapy were the influencing factors of survival and prognosis(P<0.05);multivariate analysis showed that sex,age,clinical stage,pathological type,treatment principle,duration of taking traditional Chinese medicine,operation and chemotherapy were independent prognostic factors for lung cancer patients(P<0.05).Conclusion There are many factors influencing the prognosis of lung cancer patients treated with integrated traditional Chinese and Western medicine,among which gender,age,clinical stage,pathological type,treatment principle,duration of traditional Chinese medicine,operation and chemotherapy are the main factors affecting the prognosis.
作者
张亦璐
焦丽静
许玲
ZHANG Yilu;JIAO Lijing;XU Ling(The First Department of Oncology,Yueyang Integrated Traditional and Western Medicine Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Institute of Clinical Immunology,Yueyang Integrated Traditional and Western Medicine Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Institute of Traditional Chinese Medicine Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《现代中医药》
CAS
2022年第4期119-126,共8页
Modern Chinese Medicine
基金
国家中医药管理局中医药循证能力建设项目(2019XZZX-ZL004)
上海市卫健委中西医临床协作试点项目(ZXYXZ-201901)
虹口区名中医许玲学术经验传承工作室、虹口区名中医许玲北外滩社区工作站、虹口区“国医强优”三年行动计划(2018-2020年)名中医工作室(站)建设项目(HGYMZY-2018-11)
上海市中医诊疗模式创新试点建设项目-肺癌中医诊疗身心全程管理诊疗模式创新试点(ZY(2018-2020)-FWTX-6009)。
关键词
真实世界
回顾性分析
肺癌
中西医结合治疗
生存预后
Real world
Retrospective analysis
Lung cancer
Integrated traditional Chinese and Western medicine
Survival prognosis
