摘要
目的观察稳心颗粒联合利伐沙班片治疗非ST段抬高型急性冠脉综合征(NSTE-ACS)的临床疗效。方法选取2019年7月—2020年11月成都市第三人民医院收治的112例NSTE-ACS病人为研究对象,按随机数字表法分为对照组与观察组,每组56例。对照组接受利伐沙班片治疗,观察组采用稳心颗粒联合利伐沙班片治疗。比较两组治疗前后心功能[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)]、血浆心力衰竭标志物指标[心房利钠肽(ANP)、心室脑钠肽(BNP)]、肾素-血管紧张素-醛固酮系统(RAAS)活性指标[肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)]、炎性因子[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]、血管内皮功能指标[内皮素-1(ET-1)、一氧化氮(NO)];统计两组治疗期间药物不良反应发生情况。结果治疗后,两组LVEDD、LVESD及血浆ANP、BNP、PRA、AngⅡ、IL-1、IL-6、CRP、ET-1均较治疗前明显降低(P<0.05),且观察组明显低于对照组(P<0.05);两组治疗后LVEF、NO水平均较治疗前明显升高(P<0.05),且观察组明显高于对照组(P<0.05)。两组病人药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论稳心颗粒联合利伐沙班片治疗NSTE-ACS病人,可有效减轻心肌损伤程度,抑制RAAS活性与炎症反应,并改善其血管内皮功能,安全性良好。
Objective To observe the clinical efficacy of Wenxin Granules combined with rivaroxaban tablets in the treatment of non-ST-segment elevation acute coronary syndrome(NSTE-ACS).Methods One hundred and twelve patients with NSTE-ACS were selected and randomly divided into control group and observation group,with 56 patients in each group.The patients in control group were given rivaroxaban tablets,and the patients in observation group were given rivaroxaban tablets and Wenxin Granules.The cardiac function[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)],plasma heart failure markers[atrial natriuretic peptide(ANP),ventricular brain natriuretic peptide(BNP)],renin-angiotensin-aldosterone system(RAAS)activity indicators[plasma renin activity(PRA),angiotensinⅡ(AngⅡ)],inflammatory cytokines[interleukin-1(IL-1),interleukin-6(IL-6),C-reactive protein(CRP)],and vascular endothelial function indexes[endothelin-1(ET-1),nitric oxide(NO)]were compared between two groups before treatment and after 2 weeks of treatment.The incidence of adverse drug reactions in two groups during treatment was analyzed.Results After treatment,LVEDD,LVESD,and the levels of plasma ANP,BNP,PRA,AngⅡ,IL-1,IL-6,CRP,and ET-1 of two groups were significantly decreased compared with those before treatment(P<0.05),and the levels of above indicators of observation group were significantly lower than those of control group(P<0.05).LVEF and NO in two groups were significantly increased compared with those before treatment(P<0.05),and LVEF and NO in observation group were higher than those in control group(P<0.05).There were no statistically significant differences in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Rivaroxaban tablets combined with Wenxin Granules can effectively relieve the degree of myocardial injury,inhibit RAAS activity and inflammatory response,and improve the vascular endothelial function in the treatment of patient
作者
侯维维
郭良敏
巫文丽
HOU Weiwei;GUO Liangmin;WU Wenli(Chengdu Third People′s Hospital,Chengdu 610000,Sichuan,China)
出处
《中西医结合心脑血管病杂志》
2022年第13期2393-2398,共6页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
非ST段抬高型急性冠脉综合征
稳心颗粒
利伐沙班片
心功能
心力衰竭标志物
血管内皮功能
炎性因子
non-ST-segment elevation acute coronary syndrome
Wenxin Granules
rivaroxaban
cardiac function
heart failure markers
vascular endothelial function
inflammatory factor
