摘要
目的 研究血液透析联合血液灌流治疗肾性骨营养不良的临床疗效。方法 120例肾性骨营养不良患者,根据随机数字表法分为观察组与对照组,每组60例。对照组接受血液透析治疗,观察组采用血液透析联合血液灌流治疗。比较两组临床疗效,治疗前后的血磷、血钙、甲状旁腺激素水平,临床症状消失时间、不良事件发生率。结果 观察组治疗总有效率为95.00%,高于对照组的83.33%,差异有统计学意义(P<0.05)。治疗前,两组血磷、血钙水平比较,差异无统计学意义(P>0.05);治疗后,两组血磷、血钙水平均较治疗前改善,且观察组血磷(2.08±0.11)mmol/L低于对照组的(2.56±0.23)mmol/L,血钙(2.85±0.19)mmol/L高于对照组的(2.21±0.32)mmol/L,差异有统计学意义(P<0.05)。治疗前,两组甲状旁腺激素水平比较,差异无统计学意义(P>0.05);治疗后,两组甲状旁腺激素水平均较治疗前降低,且观察组甲状旁腺激素(395.62±14.16)ng/L低于对照组的(485.84±15.13)ng/L,差异有统计学意义(P<0.05)。观察组瘙痒消失时间(1.05±0.17)周、骨痛消失时间(1.14±0.28)周、疲乏消失时间(1.13±0.22)周均短于对照组的(2.69±0.32)、(2.46±0.19)、(2.28±0.46)周,差异有统计学意义(P<0.05)。观察组不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论 对肾性骨营养不良患者,临床上采用血液透析联合血液灌流的治疗方法可获得理想效果,能够在短时间内改善患者的临床症状和相关指标,安全性高,故具有临床借鉴和推广的价值。
Objective To study the clinical efficacy of hemodialysis and hemoperfusion in the treatment of renal osteodystrophy.Methods A total of 120 patients with renal osteodystrophy were divided into observation group and control group according to random numerical table,with 60 cases in each group.The control group received hemodialysis,while the observation group received hemodialysis combined with hemoperfusion.Both groups were compared in terms of clinical efficacy,serum phosphorus,serum calcium levels and parathyroid hormone levels before and after treatment,time to disappearance of clinical symptoms,and incidence of adverse reactions.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 83.33%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in levels of serum phosphorus and blood calcium between the two groups(P>0.05).After treatment,the levels of serum phosphorus and calcium in the two groups were improved compared with those before treatment,and the level of serum phosphorus(2.08±0.11)mmol/L in the observation group was lower than(2.56±0.23)mmol/L in the control group,and the level of serum calcium(2.85±0.19)mmol/L was higher than(2.21±0.32)mmol/L of the control group.All the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in parathyroid hormone level between the two groups(P>0.05).After treatment,the levels of parathyroid hormone in the two groups were lower than those before treatment in this group,and the parathyroid hormone(395.62±14.16)ng/L in the observation group was lower than(485.84±15.13)ng/L in the control group,and the difference was statistically significant(P<0.05).The disappearance time of pruritus(1.05±0.17)weeks,disappearance time of bone pain(1.14±0.28)weeks,and fatigue disappearance time(1.13±0.22)weeks in the observation group were all shorter than(2.69±0.32),(2.46±0.19)
作者
唐福仙
梁苇茜
庞欣杰
TANG Fu-xian;LIANG Wei-xi;PANG Xin-jie(Department of Nephrology,People's Hospital of Huaiji County,Zhaoqing 526400,China)
出处
《中国现代药物应用》
2022年第11期46-49,共4页
Chinese Journal of Modern Drug Application
