摘要
目的:研究肝吸虫(华支睾吸虫)感染对非酒精性脂肪性肝病(NAFLD)患者脂肪代谢及肝纤维化的影响。方法:收集NAFLD合并肝吸虫感染患者39例为肝吸虫组,NAFLD患者43例为对照组,检测两组患者的肝功能[谷草转氨酶(AST)和谷丙转氨酶(ALT)]、肝纤维化四项[透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PⅢP)、层黏连蛋白(LN)];血脂[总胆固醇(Chol)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)]、肝脏硬度值以及脂肪衰减指标。结果:肝吸虫组患者脂肪衰减指标与对照组比较,差异具有统计学差异(P<0.05);而其他各项指标在两组患者间比较,差异均无统计学意义。结论:NAFLD合并肝吸虫感染患者肝脏脂肪含量比单纯NAFLD患者明显降低。
Objective:To study the effect of Clonorchis sinensis infection on fat metabolism and liver fibrosis in NAFLD patients.Methods:A total of 39 patients with nonalcoholic fatty liver disease(NAFLD)complicated with liver fluke infection were collected as the liver fluke group and 43 patients with NAFLD as the control group.The liver functions of the two groups were detected:aspartate aminotransferase(AST),alanine aminotransferase(ALT),liver fibrosis:hyaluronic acid(HA),type IV collagen(Ⅳ-C),typeⅢprocollagen(PⅢP),laminin blood lipid:total cholesterol(CHOL),triglyceride(TG),high density lipoprotein(HDL),procollagenⅢpeptide(LDL)and non-invasive liver fibrosis test(Fibro Touch):liver stiffness and fat attenuation.Results:The difference in fat attenuation of patients between the two groups was statistically significant(P<0.05).Conclusion:Liver fat content of patients with NAFLD combined with liver fluke infection is significantly lower than that of patients with NAFLD alone.
作者
吴铁雄
刘旭东
李品桦
黄露
朱沪敏
庞华珍
WU Tie-xiong;LIU Xu-dong;LI Ping-hua(Guangxi University of Chinese Medicine(Nanning,530200),China.)
出处
《中西医结合肝病杂志》
CAS
2022年第7期588-590,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
国家自然科学基金面上项目(No.81473532)
广西省重点研发计划(No.桂科AB18221009)
2019年广西省一流学科建设课题(No.2019XK139)
广西中医药大学研究生教育创新计划项目(No.XYJ19117)
