摘要
目的:研究经鼻内窥镜垂体瘤切除术(RERPA)对垂体瘤患者生长激素(GH)、泌乳素(PRL)、促肾上腺皮质激素(ACTH)及汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)评分的影响。方法:选择2020年3月-2020年12月于常德市第一中医医院进行治疗的垂体瘤患者80例,使用电脑随机数字表法将其分为两组,每组40例。对照组应用显微镜下经过鼻蝶入路行垂体瘤切除手术,观察组应用RERPA。对比及分析两组手术情况,GH、PRL、ACTH及HAMA、HAMD评分,并发症发生情况。结果:观察组手术时间、术中出血量、肿瘤全切比例及术后住院时间均优于对照组(P<0.05)。观察组术后GH、PRL、ACTH水平及HAMA、HAMD评分均低于对照组(P<0.05)。观察组术后并发症发生率为7.50%,明显低于对照组的25.00%(P<0.05)。结论:对垂体瘤患者应用RERPA,能有效减少术中出血量,提高肿瘤全切比例,减少手术时间及术后住院时间,改善其血清GH、PRL及ACTH水平,缓解其焦虑、抑郁等不良情绪,且安全性较高,值得在临床上推广。
Objective:To study the effect of ransnasal endoscopic resection of pituitary adenoma(RERPA)on growth hormone(GH),prolactin(PRL),adrenocorticotropic hormone(ACTH),Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)scores in patients with pituitary tumor.Method:A total of 80 patients with pituitary tumor treated in No.1 Hospital of Traditional Chinese Medicine of Changde City from March 2020 to December 2020 were selected,they were divided into two groups according to computer random number table method,40 cases in each group.The control group was given microscopic pituitary tumor resection via nasal butterfly approach,and the observation group was given RERPA.The operation conditions,GH,PRL,ACTH and HAMA,HAMD scores,occurrence of complications condition of two groups were compared and analyzed.Result:The operation time,intraoperative bleeding,total tumor resection ratio and postoperative hospital stay in the observation group were better than those in the control group(P<0.05).The levels of GH,PRL and ACTH,HAMA and HAMD scores in the observation group after operation were lower than those in the control group(P<0.05).The postoperative complication rate in the observation group was 7.50%,which was significantly lower than 25.00%in the control group(P<0.05).Conclusion:Using RERPA in pituitary tumor patients can effectively reduce the amount of intraoperative bleeding,the proportion of total tumor resection,operation time and hospital stay time,improve their serum GH,PRL and ACTH levels,relieve their anxiety,depression and other adverse emotions,which is worth the clinical promotion.
作者
张辉喜
ZHANG Huixi(No.1 Hospital of Traditional Chinese Medicine of Changde City,Hunan Province,Changde 415000,China)
出处
《中国医学创新》
CAS
2022年第19期149-152,共4页
Medical Innovation of China
