摘要
目的:探讨耐药性妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN)患者的临床资料,分析发生耐药的可能因素。方法:回顾性选取2010年1月-2018年1月桂林医学院附属医院收治的耐药性GTN患者40例。收集及分析40例患者的临床资料,分析40例患者耐药后治疗方案及疾病转归。结果:40例患者中,22例患者距离前次妊娠时间>1年,30例患者发生转移,30例患者初始化疗前血清β-hCG>10^(4)U/L。初始化疗采用单药化疗方案17例,采用联合化疗方案23例,耐药后均采用联合化疗方案,其中3例患者行子宫全切术。随访3~10年,37例患者治愈,3例患者死亡,总体治愈率92.5%。结论:GTN患者具有发病潜伏期长、高水平血清β-hCG、存在转移病灶易发生耐药,耐药性GTN采用联合化疗是高度可治愈的,联合化疗辅助手术治疗可以增加患者的治愈率。
Objective:To investigate the clinical data of patients with drug resistance gestational trophoblastic neoplasia(GTN)and analyze the possible factors of drug resistance.Method:A total of 40 patients with drug resistance GTN treated in The Affiliated Hospital of Guilin Medical University from January 2010 to January 2018 were selected retrospectively.The clinical data of 40 patients were collected and analyzed,and the treatment scheme and disease outcome of 40 patients after drug resistance were analyzed.Result:Among the 40 patients,22 patients had more than 1 year since their previous pregnancy,30 patients had metastasis,and 30 patients had serumβ-hCG>10^(4)U/L before initial chemotherapy.The initial chemotherapy was single drug chemotherapy in 17 patients and combined chemotherapy in 23 patients.After drug resistance,combined chemotherapy was used,of which 3 cases underwent total hysterectomy.Following up for 3-10 years,37 patients were cured and 3 patients died.The overall cure rate was 92.5%.Conclusion:Patients with GTN have long incubation period,high level of serumβ-hCG,and metastatic lesions are prone to drug resistance.Drug resistance GTN is highly curable with combined chemotherapy.Combined chemotherapy combined with surgery treatment can increase the cure rate of patients.
作者
佘远萍
杨冰
SHE Yuanping;YANG Bing(The Affiliated Hospital of Guilin Medical University,Guilin 541001,China;不详)
出处
《中外医学研究》
2022年第16期130-133,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
广西自然科学基金项目(2018GXNSFAA281170)。
关键词
妊娠滋养细胞肿瘤
化疗
耐药
Gestational trophoblastic neoplasia
Chemotherapy
Drug resistance
