摘要
各种急性损伤因素作用于慢性肝病后,可导致病情急剧恶化,发展为慢加急性肝衰竭(ACLF)。肝病患者体内,肠道菌群毒素可通过门静脉或体循环至肝脏导致肝细胞死亡,此外,肠道菌群可通过多种机制发生移位,诱导感染、血管扩张和全身炎症反应发生,促使疾病进展为失代偿期肝硬化和ACLF,最终危及患者生命。本文梳理了近5年的相关研究成果,阐述肠道菌群在ACLF发生、发展、防治中的意义。肠道菌群及其代谢产物对肝病进展有着重大影响,因此有必要深入研究肠道菌群在ACLF病因学中的作用,为ACLF的诊断和治疗拓展新思路。
Various acute injury factors may act on chronic liver diseases and then lead to the rapid deterioration of disease conditions,which further develops into acute-on-chronic liver failure(ACLF).In patients with liver disease,gut microbiota toxins enter the liver through the portal vein or systemic circulation and thus lead to the death of hepatocytes;in addition,gut microbiota translocation occurs through various mechanisms,induces infection,vasodilation,and systemic inflammation,and then promotes disease progression to decompensated liver cirrhosis and ACLF,which ultimately endangers the life of patients.This article summarizes related research findings in the recent five years and elaborates on the significance of gut microbiota in the development,progression,prevention,and treatment of ACLF.Gut microbiota and its metabolites have a significant impact on the progression of liver disease,and therefore,it is necessary to conduct in-depth studies on the role of gut microbiota in the etiology of ACLF,in order to provide new ideas for the diagnosis and treatment of ACLF.
作者
王富春
李子怡
张万洁
毛小荣
李俊峰
WANG Fuchun;LI Ziyi;ZHANG Wanjie;MAO Xiaorong;LI Junfeng(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Department of Infectious Diseases,The First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Infectious Diseases&Institute of Infectious Diseases,The First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第7期1667-1670,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金(81800528)
甘肃省自然科学基金(20JR5RA364)
兰州大学第一医院院内基金(ldyyyn2020-02,ldyyyn2020-14)
甘肃省感染肝病临床医学研究中心(21JR7RA392)。
关键词
慢加急性肝功能衰竭
胃肠道微生物组
诊断
治疗学
Acute-On-Chronic Liver Failure
Gastrointestinal Microbiome
Diagnosis
Therapeutics
