摘要
目的:探讨丁苯酞联合法舒地尔对老年急性脑梗死疗效及炎症因子水平影响。方法:回顾性分析2019年2月—2020年9月安阳市第六人民医院收治的145例老年急性脑梗死患者的临床资料,以治疗方法不同分为研究组77例和对照组68例,对照组给予丁苯酞治疗,研究组在此基础上另给予法舒地尔治疗,观察两组患者临床疗效,比较两组患者治疗前后炎症因子水平,记录两组患者治疗期间发生的不良反应。结果:治疗前1 d,两组患者血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平对比,差异有统计学意义(t=1.852、0.081、0.104,P<0.05);治疗2周后,对照组患者血清IL-6、TNF-α、CRP水平均比治疗前1 d低,差异有统计学意义(t=10.733、16.030、14.275,P<0.05),研究组血清IL-6、TNF-α、CRP水平均比治疗前1 d低,差异有统计学意义(t=25.55、31.63、37.43,P<0.05),且研究组血清IL-6、TNF-α、CRP水平比对照组低,差异有统计学意义(t=8.35、15.01、16.09,P<0.05)。研究组患者总有效率有效率比对照组高,差异有统计学意义(χ^(2)=4.068,P<0.05)。两组患者治疗期间不良反应发生率相近,差异无统计学意义(χ^(2)=0.010,P>0.05)。结论:丁苯酞联合法舒地尔治疗老年急性脑梗死患者疗效确切,可减轻机体炎症反应,且安全可靠。
Objective:To investigate the effect of butylphthalide combined with fasudil on the effect of senile acute cerebral infarction and the level of inflammatory factors.Methods:The clinical data of 145 elderly patients with acute cerebral infarction who were treated in the hospital from February 2019 to September 2020 were retrospectively analyzed,and they were divided into study group 77 coses and control group 68 coses.The control group was treated with butylphthalide,and the study group was additionally treated with fasudil.The clinical efficacy of the two groups was observed,the levels of inflammatory factors before and after treatment in the two groups were compared,and the adverse reactions occurred in the two groups during the treatment were recorded.Results:1 d before treatment,there were statistically significant differences in serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)levels between the two groups(t=1.852,0.081,0.104,P<0.05).After 2 weeks of treatment,the levels of serum IL-6,TNF-αand CRP in the control group were lower than those before 1 d of treatment,and the difference was statistically significant(t=10.733,16.030,14.275,P<0.05).Serum levels of IL-6,TNF-αand CRP in the study group were lower than those 1 d before treatment,and the difference was statistically significant(t=25.55,31.63,37.43,P<0.05).The serum levels of IL-6,TNF-αand CRP in the study group were lower than those in the control group,and the difference was statistically significant(t=8.35,15.01,16.09,P<0.05).The total effective rate of patients in the study group was higher than that in the control group,and the difference was statistically significant(χ^(2)=4.068,P<0.05).The incidence of adverse reactions in the two groups during treatment was similar,and the difference was not statistically significant(χ^(2)=0.010,P>0.05).Conclusion:Butylphthalide combined with fasudil in the treatment of elderly patients with acute cerebral infarction is effective,can reduce the body’s inflammatory respons
作者
李伟
LI Wei(Department of Neurology,Anyang Sixth People’s Hospital,Anyang,Henan,455000,China)
出处
《黑龙江医学》
2022年第11期1352-1354,共3页
Heilongjiang Medical Journal
关键词
丁苯酞
老年急性脑梗死
炎症因子水平
法舒地尔
临床疗效
Butylphthalide
Acute cerebral infarction in the elderly
Inflammatory factor levels
Fasudil
Clinical efficacy
