摘要
色胺类物质是一类与神经递质5-羟色胺化学结构相似的新型精神活性物质,通过与5-羟色胺受体结合,产生致幻效应。这类物质是致幻剂中的一大类,其致幻效应强烈,作用时间长,严重威胁吸食者健康和公共安全。近年来,色胺类物质在多个国家出现滥用,但目前仅有小部分在国际上受到管控。一些色胺类物质对生理、认知、情感和脑功能相关疾病有治疗作用,故其在治疗物质使用障碍、抑郁症、焦虑症和强迫症等方面被认为具有较大潜力。本文对色胺类物质在全球滥用情况和管控状况及其药理作用和临床研究进展进行综述,以期为色胺类物质的研究提供参考。
Tryptamines are a class of new psychoactive substances with a chemical structure similar to that of the neurotransmitter serotonin.They produce hallucinogenic effects by binding to serotonin receptors.This type of substance is a large class of hallucinogens and has a strong hallucinogenic effect and a long action time,which poses a serious threat to the health of smokers and public safety.In recent years,tryptamine substances have been abused in many countries,but only a small part of tryptamine substances is currently under international control.Some tryptamines have therapeutic effects on physiology,cognition,emotion and brain function,so they are considered to have great potential in the treatment of substance use disorders,depression,anxiety,obsessive-compulsive disorder and other diseases.In this paper,the current global abuse,control measures,pharmacological effects and clinical researches of tryptamines are reviewed in order to provide reference for future research on tryptamines.
作者
李楠
何浩
李锋
魏佳韵
乔艳玲
王优美
徐鹏
狄斌
LI Nan;HE Hao;LI Feng;WEI Jia-yun;QIAO Yan-ling;WANG You-mei;XU Peng;DI Bin(China Pharmaceutical University,Nanjing 210009,China;Office of China National Narcotics Control Commission-China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control,Beijing 100193,China;Public Security Bureau of Wulian County,Rizhao City,Shandong Province,Rizhao 262300,China;Key Laboratory of Drug Monitoring and Control,Drug Intelligence and Forensic Center,Ministry of Public Security,Beijing 100193,China)
出处
《中国药理学与毒理学杂志》
CAS
北大核心
2022年第5期378-384,共7页
Chinese Journal of Pharmacology and Toxicology
基金
国家重点研发计划(2018YFC0807402)。
关键词
色胺类物质
药物滥用
药理作用
临床研究
tryptamines
drug abuse
pharmacological effects
clinical researches
