摘要
目的探讨吡格列酮治疗脓毒症急性肝损伤患者的临床效果。方法选择2019年10月至2020年10月在我院确诊并进行治疗的96例脓毒症急性肝损伤患者作为研究对象,依据入院顺序将其分为对照组和试验组,各48例。对照组给予脓毒症急性肝损伤常规治疗,试验组在对照组基础上给予吡格列酮治疗。比较两组治疗前、后的炎症氧化应激因子[丙二醛(MDA)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)]、肝功能指标[丙氨酸氨基转移酶(ALT)、γ-谷氨酰转肽酶(GGT)、天门冬酸氨基转移酶(AST)、血清总胆红素(STB)]、感染相关性器官功能衰竭评价(SOFA)、急性生理功能和慢性健康状况评分系统Ⅱ(APACHEⅡ)评分。结果治疗后,两组的MDA水平均降低,CAT、GSH-Px、SOD水平均升高,且试验组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的ALT、GGT、AST、STB水平均降低,且试验组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的SOFA、APACHEⅡ评分均降低,且试验组低于对照组,差异具有统计学意义(P<0.05)。结论吡格列酮能够有效抑制脓毒症急性肝损伤患者的炎症氧化应激,减轻肝功能损伤,促进疾病转归。
Objective To investigate the clinical effect of pioglitazone in the treatment of patients with acute liver injury in sepsis.Methods A total of 96 patients with acute liver injury in sepsis diagnosed and treated in our hospital from October 2019 to October 2020 were selected as the research objects.The patients were divided into control group and experimental group according to the admission order,with 48 cases in each group.The control group was given routine treatment for acute liver injury in sepsis,and the experimental group was given pioglitazone on the basis of the control group.The inflammatory oxidative stress factors[malondialdehyde(MDA),catalase(CAT),glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)],liver function indexes[alanine aminotransferase(ALT),gamma glutamyl transferase(GGT),aspartate aminotransferase(AST)and serum total bilirubin(STB)],sepsis related organ failure assessment(SOFA)and acute physiology and chronic health evaluationⅡ(APACHEⅡ)scores between the two groups before and after treatment were compared.Results After treatment,the level of MDA decreased and the levels of CAT,GSH-Px and SOD increased in the two groups,and those in the experimental group were better than the control group,the differences were statistically significant(P<0.05).After treatment,the levels of ALT,GGT,AST and STB in the two groups decreased,and those in the experimental group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,the scores of SOFA and APACHEⅡin the two groups decreased,and those in the experimental group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion Pioglitazone can effectively inhibit inflammatory oxidative stress in patients with acute liver injury in sepsis,reduce liver function injury,and promote disease outcome.
作者
杨琳琳
YANG Linlin(Pharmacy Department,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)
出处
《临床医学研究与实践》
2022年第21期39-41,共3页
Clinical Research and Practice
关键词
吡格列酮
脓毒症急性肝损伤
炎症氧化应激
pioglitazone
acute liver injury in sepsis
inflammatory oxidative stress
