摘要
目的通过比较慢性阻塞性肺疾病(COPD)患者血清抗炎细胞因子白细胞介素(IL)-10和促炎细胞因子IL-6、肿瘤坏死因子(TNF-α)、人γ干扰素(IFN-γ)浓度的差异及肺功能变化,初步探讨4种细胞因子在COPD病情进展中的作用。方法选择2020年10月至2022年1月该院呼吸内科收治的100例稳定期COPD诊断标准的男性患者,检测入院时的血清IL-6、TNF-α、IFN-γ、IL-10及肺功能,IL-10水平健康者(50例)纳入对照组,IL-10水平升高者(50例)纳入实验组,比较两组患者血清IL-6、TNF-α、IFN-γ水平及入院时和对症治疗7 d后的肺功能。结果入院时实验组的第1秒用力呼气容积(FEV1%)明显低于对照组;实验组的IL-6、TNF-α、IFN-γ水平均高于对照组,比较差异有统计学意义(P<0.05);实验组中IL-10与IL-6水平呈正相关(r s=0.544,P<0.05)。治疗后,对照组FEV1/用力肺活量(FVC)、FEV%比入院时均有改善,比较差异有统计学意义(P<0.05),实验组FEV1/FVC、FEV%比无明显变化,差异无统计学意义(P>0.05)。结论IL-10与IL-6、TNF-α、IFN-γ同时升高预示着COPD即将进入急性加重期;促炎因子IL-6、TNF-α、IFN-γ尤其是IL-6在疾病进展期时升高可能会反馈性促进IL-10的分泌;肺功能分级较高者血清促炎因子水平较高,发生急性加重的概率可能会增加。
Objective To compare the serum anti-inflammatory cytokine IL-10 and pro-inflammatory cytokines between the experimental group and the control group in chronic obstructive pulmonary disease(COPD)patients.The differences in the concentrations of IL-6,tumor necrosis factors,human interferon gamma(IFN-γ)and the changes in lung function were used to preliminarily explore the role of the above four cytokines in the progression of COPD.Methods From October 2020 to January 2022,a total of 100 male patients who were admitted to the hospital according to the diagnostic criteria were selected,the serum IL-6,TNF-α,IFN-γ,IL-10 and pulmonary function were detected at admission.Those with healthy IL-10 level(50 cases)were included in the control group,and The patients whose IL-10 level increased(50 cases)were admitted to the experimental group,and the serum levels of IL-6,TNF-α,IFN-γ and the pulmonary function at admission and after 7 days of symptomatic treatment were compared between the two groups.Results Forced expiratory volume in the first second(FEV1%)of the experimental group was significantly lower than that of the control group at admission;the levels of IL-6,TNF-α and IFN-γ in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05);the levels of IL-10 and IL-6 in the experimental group were positively correlated(r s=0.544,P<0.05).After treatment,FEV1/Forced vital capacity(FVC)and FEV1 in the control group were improved as compared with those at admission,the differences were statistically significant(P<0.05),while in the experimental group,FEV1/FVC and FEV% were not compared with those at admission(P>0.05).Conclusion The simultaneous increase of IL-10,IL-6,TNF-α and IFN-γ indicates that COPD is about to enter the acute exacerbation stage;the increase of IL-10 may feed back the secretion of IL-10;the serum proinflammatory factor level is higher in people with higher pulmonary function classification,and the probability of acute exacerbation may
作者
高瑞
岳保红
GAO Rui;YUE Baohong(School of Basic Medicine,Zhengzhou University,Zhengzhou,Henan 450001,China)
出处
《检验医学与临床》
CAS
2022年第S01期89-92,共4页
Laboratory Medicine and Clinic
关键词
慢性阻塞性肺疾病
肿瘤坏死因子
人γ干扰素
chronic obstructive pulmonary disease
tumor necrosis factors
human interferon gamma
