摘要
Pathogenic bacterial infection is severely threatening public health globally.The multi-modal antibacterial nanoplatforms could significantly improve the antibacterial efficiency.Here,we report a metal(Ti)-organic framework(MOF)derived nanocarbon(C-Ti-MOF)as a biosafety material for synergistic sterilization of pathogenic bacteria via efficient photodynamic catalysis and robust photothermal effects.The C-Ti-MOF consists of abundant TiO_(2) nanodots embedded in graphitic carbon frameworks.Under visible light irradiation,TiO_(2) nanodots can catalyze H_(2)O_(2) and O_(2) to produce superoxide anion(•O_(2)^(–))and singlet oxygen(1O2),respectively.Meanwhile,under near-infrared irradiation(NIR),C-Ti-MOF can generate massive heat to destroy bacterial membranes.Systematic antibacterial experiments reveal that the C-Ti-MOF nanoagents have a long-lasting and nearly 100%bactericidal ratio at an extremely low dose(0.16 mg/mL),which is much better than the state-of-the-art TiO_(2)(Commercial TiO_(2)(P25),0.64 mg/mL).Furthermore,the C-Ti-MOF can be electrospun into an antibacterial nanofiber membrane via mixing with polymeric matrix for treating bacteriacontaminated wastewater,and the membranes possess integrated antibacterial activity and excellent biocompatibility.Our study demonstrates a promising Ti-MOF-based biosafety material for efficient and long-life disinfection,which may stimulate new research in MOF-related biological applications in various disciplines ranging from water decontaminations to nanotherapeutics.
基金
supported by the National Key R&D Program of China(2021YFE0205000)
National Natural Science Foundation of China(Nos.52161145402,52173133,82102064,82102065,82001020,and 82001829)
the Science and Technology Project of Sichuan Province(Nos.2021YFH0135,2021YFS0050,2021YJ0434,2021YFH0180,2021YFH0087,and 2021YFG0238)
the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Grant No.ZYJC21047)
the innovation project of Med-X Center for Materials,Sichuan University(Grant No.MCM202102)
the China Postdoctoral Science Foundation(Grant Nos.2021 M702334,2021 M692291,2021 M692288,and 2021 M692303)
the Post-Doctor Research Project,West China Hospital,Sichuan University(Grant Nos.2021SCU12034,2021SCU12013,and 2020HXBH071)
Prof.Cheng acknowledges the financial support of the State Key Laboratory of Polymer Materials Engineering(Grant No.sklpme2021-4-02)
Fundamental Research Funds for the Central Universities.
