摘要
目的探讨术前中性粒细胞/淋巴细胞比值(NLR)在判断肺腺癌患者中术后复发和生存情况的临床价值。方法回顾性分析2006年7月至2010年12月大连医科大学附属第一医院收治的215例经病理证实为肺腺癌并行肺腺癌根治术患者的临床资料。通过受试者工作特征曲线(ROC)得出NLR的临界值,并以此把215例患者分为高NLR组、低NLR组。采用χ^(2)检验,比较NLR与临床及病理特征的关系,采用Kaplan-Meier绘制生存曲线和Cox回归分析NLR对肺腺癌患者术后复发[无病生存时间(DFS)]及生存[总生存时间(OS)]的影响。结果NLR临界值为1.785,高NLR组83例,低NLR组132例。高NLR组患者复发率高于低NLR组,低NLR组5年生存率和无病生存率显著高于高NLR组,差异均有统计学意义(P<0.05)。单因素和多因素生存分析显示:有无胸膜侵犯、TNM分期及术前NLR是预测肺腺癌患者术后复发(DFS)的独立指标(P<0.05);肿瘤分化程度、TNM分期及术前NLR是肺腺癌患者术后生存(OS)的独立预后因素(P<0.05)。结论术前NLR检测可作为判断肺腺癌患者术后复发及生存的预后指标。
Objective To investigate the clinical value of preoperative neutrophil-lymphocyte ratio(NLR)in predicting postoperative recurrence and survival in patients with lung adenocarcinoma.Methods The clinical data of 215 patients with lung adenocarcinoma confirmed by pathology and undergoing radical pulmonary adenocarcinoma admitted to the First Affiliated Hospital of Dalian Medical University from July 2006 to December 2010 were retrospectively analyzed.The critical values of NLR were obtained by receiver operating characteristic(ROC)curve,and 215 patients were divided into high NLR group and low NLR group.Chi-square test was used to compare the relationship between NLR and clinical and pathological features.Survival curves were plotted using the Kaplan-Meier Method,and Cox regression analysis were used to analyze the effects of NLR on postoperative recurrence[disease-free survival(DFS)]and survival[overall survival(OS)]in patients with lung adenocarcinoma.Results The critical value of NLR was 1.785,with 83 cases in the high NLR group and 132 cases in the low NLR group.The recurrence rate was higher in the high NLR group than those in the low NLR group,the 5-year survival rate and disease-free survival rate in the low NLR group were significantly higher than those in the high NLR group,with statistically significant differences(P<0.05).Univariate and multivariate survival analyses showed that pleural invasion,TNM stage and preoperative NLR were independent indicators for predicting(DFS)in the patients with lung adenocarcinoma(P<0.05);tumor differentiation,TNM stage and preoperative NLR were independent prognostic factors for postoperative(OS)in the patients with lung adenocarcinoma(P<0.05).Conclusion The preoperative NLR detection can be used as a prognostic indicator for postoperative recurrence and survival of patients with lung adenocarcinoma.
作者
吴兰
范原铭
高亚杰
侯婧
涂辉阳
朱勇
WU Lan;FAN Yuanming;GAO Yajie;HOU Jing;TU Huiyang;ZHU Yong(Department of Oncology,North-Kuanren General Hospital,Chongqing 401121,China;The second Department of General Surgery,People's Hospital of Changshou Chongqing,Chongqing,401220,China;Department of Oncology,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116000,China;Department of Oncology,People's Hospital of Changshou Chongqing,Chongqing 401220,China;Department of Oncology,Jiujiang No.1 People's Hospital,Jiujiang,Jiangxi 332001,China)
出处
《现代医药卫生》
2022年第13期2192-2197,共6页
Journal of Modern Medicine & Health
基金
重庆市卫生健康委员会医学科研项目(2017ZBXM025)。
关键词
肺肿瘤
中性粒细胞/淋巴细胞比值
生存
预后
复发
预后指标
Lung neoplasm
Neutrophil/lymphocyte ratio
Survival
Prognosis
Recurrence
Prognostic indicator
