摘要
目的探讨紫杉醇+顺铂化疗在晚期非小细胞肺癌(NSCLC)患者中的应用效果。方法选取2020年7月至2021年1月于阳江市人民医院住院治疗的50例晚期NSCLC患者作为研究对象,根据治疗方法不同分为观察组与对照组,各25例。对照组患者予以放疗治疗,观察组患者在对照组基础上采用紫杉醇+顺铂化疗,比较两组临床疗效、血清肿瘤标志物水平、不良反应发生率、肺癌患者生存质量测定量表(FACT-L)评分。结果观察组治疗有效率(80.00%)高于对照组(54.00%),观察组治疗后血清糖类抗原242(CA242)、糖类抗原19-9(CA19-9)、癌胚抗原(CEA)水平低于对照组,观察组治疗后FACT-L评分高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率(16.00%)与对照组(20.00%)比较,差异无统计学意义(P>0.05)。结论紫杉醇+顺铂化疗可有效抑制晚期NSCLC患者疾病进展,降低血清肿瘤标志物水平,改善生命质量,且不良反应较少。
Objective To analyze the effect of paclitaxel plus cisplatin chemotherapy in patients with advanced NSCLC.Methods 50 patients with advanced NSCLC in Yangjiang People’s Hospital from July 2020 to January 2021 were selected and divided into two groups according to "different treatment methods". 25 patients in the control group were treated with radiotherapy, and 25patients in the observation group were treated with paclitaxel plus cisplatin chemotherapy on the basis of the control group. The clinical efficacy, serum tumor markers, incidence of side effects and FACT-L score of the two groups were compared. Results The clinical effective rate of the observation group(80.00%) was higher than that of the control group(54.00%), the serum CA242, CA19-9 and CEA levels of the observation group after treatment were lower than those of the control group, the FACT-L score of the observation group after treatment was higher than that of the control group, the differences were statistically significant(P<0.05). The incidence of adverse reactions in the observation group(16.00%) was compared with that in the control group(20.00%), there was no significant difference(P>0.05). Conclusion Paclitaxel plus cisplatin chemotherapy can effectively inhibit the disease progression of patients with advanced NSCLC, reduce the level of serum tumor markers, improve the quality of life, and has less toxic and side effects.
作者
程典文
吴成焱
吴幸谕
李劲
CHENG Dian-Wen;WU Cheng-Yan;WU Xing-Yu;LI Jin(Second Department of Oncology,Yangjiang People's Hospital,Yangjiang 529500,China)
出处
《中国药物经济学》
2022年第5期80-83,共4页
China Journal of Pharmaceutical Economics
基金
阳江市科学技术局科研项目(阳科通[2019]50号-21)
阳江市科学技术局科研项目(阳科通[2019]50号-22)。
关键词
紫杉醇
顺铂
晚期
非小细胞肺癌
临床疗效
Paclitaxel
Cisplatin
Advanced
Non-small cell lung cancer
Clinical efficacy
