摘要
目的 观察泮托拉唑与生长抑素联合治疗消化性溃疡伴出血的疗效。方法 92例消化性溃疡伴出血患者作为研究对象,随机分为对照组和联合组,各46例。两组入院后均进行基础治疗,对照组在基础治疗基础上予以泮托拉唑治疗,联合组在对照组基础上使用生长抑素进行辅助治疗。比较两组患者止血时间和输血率,炎症因子[血清C反应蛋白(CRP)、白细胞介素-1(IL-1)]水平,胃液酸碱度(pH)值、胃泌素(GAS)水平,药物不良反应发生情况。结果 联合组患者止血时间(10.25±3.48)h明显短于对照组的(25.87±5.15)h,输血率15.22%明显低于对照组的34.78%,差异具有统计学意义(P<0.05)。两组患者血清CRP、IL-1水平均显著低于治疗前,且联合组患者血清CRP(7.64±2.06)mg/L、IL-1(45.34±9.12)ng/L均明显低于对照组的(8.56±2.03)mg/L、(48.76±6.84)ng/L,差异具有统计学意义(P<0.05)。治疗5 d后,两组患者胃液pH值均较治疗前显著升高,且联合组胃液pH值(6.23±2.12)明显高于对照组的(4.97±1.08),差异具有统计学意义(P<0.05);治疗5 d后,两组患者血清GAS水平均较治疗前显著降低,且联合组患者血清GAS(89.49±12.52)μmol/L明显低于对照组的(95.28±10.78)μmol/L,差异具有统计学意义(P<0.05)。两组药物不良反应发生率比较差异无统计学意义(P>0.05)。结论 泮托拉唑与生长抑素联合治疗消化性溃疡伴出血能够有效缩短止血时间、降低输血率,改善患者炎症状态,升高胃液pH值,促进胃黏膜修复,且药物安全性较高,具有较高临床应用价值。
Objective To observe the efficacy of pantoprazole combined with somatostatin in the treatment of peptic ulcer with bleeding. Methods A total of 92 cases of peptic ulcer with bleeding were selected as the research subjects, and were randomly divided into the control group and the combined group, with 46 cases in each group. Both groups received basic therapy after admission, the control group received pantoprazole on the basis of basic therapy, and the combined group received somatostatin on the basis of the control group. Both groups were compared in terms of hemostasis time, blood transfusion rate, inflammatory factors [serum C-reactive protein(CRP), interleukin-1(IL-1)] levels, pH value, gastrin(GAS) level, and occurrence of adverse drug reactions. Results The hemostasis time(10.25±3.48) h in the combined group was significantly shorter than(25.87± 5.15) h in the control group, and the blood transfusion rate 15.22% was significantly lower than 34.78% in the control group. All the differences were statistically significant(P<0.05). The serum CRP and IL-1 levels in both groups were significantly lower than those before treatment in this group;the serum CRP(7.64±2.06) mg/L and IL-1(45.34±9.12) ng/L in the combined group were significantly lower than(8.56±2.03) mg/L and(48.76± 6.84) ng/L in the control group;all the differences were statistically significant(P<0.05). After 5 d of treatment, the gastric juice pH value in the two groups was significantly higher than that before treatment in this group, and the gastric juice pH value(6.23±2.12) in the combined group was significantly higher than(4.97±1.08) in the control group. All the differences were statistically significant(P<0.05). After 5 d of treatment, the serum GAS levels in the two groups were significantly lower than those before treatment in this group, and the serum GAS(89.49± 12.52) μmol/L in the combined group was significantly lower than(95.28±10.78) μmol/L in the control group. All the differences were statistically significant(P<0.05). Th
作者
杨智超
孙晓丹
霍明月
YANG Zhi-chao;SUN Xiao-dan;HUO Ming-yue(Department of Gastroenterology,Fuxin Central Hospital,Fuxin 123000,China)
出处
《中国现代药物应用》
2022年第10期22-25,共4页
Chinese Journal of Modern Drug Application
