摘要
目的 探讨全身热疗在中晚期结肠癌患者中的应用价值。方法 选择2019年2月~2020年6月广州市花都区人民医院收治的中晚期结肠癌患者80例,按照随机数字法分为两组,每组各40例。对照组行单纯化疗,观察组联合41.8℃全身热疗,比较两组治疗过程中(治疗前、治疗1周后、治疗1个疗程后)的皮质醇水平变化,统计两组实体肿瘤治疗效果,比较两组治疗1年内肿瘤控制率、肿瘤增大率及远处转移率,统计1年期内两组生存情况。结果 治疗1周后和治疗1个疗程后,观察组皮质醇水平分别为(318.02±17.31)pmol/L和(286.32±13.12)pmol/L,均低于对照组的(585.51±22.42)pmol/L和(574.41±21.91)pmol/L(t=59.776和71.402,均P<0.001);观察组完全缓解率为57.5%,高于对照组的27.5%(χ^(2)=7.366,P<0.05),疾病进展率为7.50%,显著低于对照组的30.0%(χ^(2)=5.251,P<0.05),治疗1年内观察组肿瘤控制率为90.00%,高于对照组的67.5%(χ^(2)=4.781,P=0.029<0.05),远处转移率为2.50%,低于对照组的25.0%(χ^(2)=6.746,P=0.009<0.05);随访1年,观察组死亡10例,存活率为75.00%,对照组死亡26例,存活率为35.00%,观察组1年生存率高于对照组(P<0.05)。结论 针对中晚期结肠癌患者联合全身热疗,能有效降低机体应激反应,提高肿瘤控制率,减少治疗远处转移率,延长患者生存时间。
Objective To explore the application value of whole body hyperthermia(WBH) in patients with middle and advanced colon cancer. Methods A total of 80 patients with middle and advanced colon cancer admitted to Huadu District People′s Hospital of Guangzhou from February 2019 to June 2020 were selected as study subjects. They were divided into two groups according to the random number method, with 40 patients in each group. The control group was treated with chemotherapy alone, while the observation group was treated with chemotherapy combined with 41.8℃WBH. The changes of cortisol levels during the treatment process(before treatment, after 1 week of treatment and after1 course of treatment) were compared between the two groups, and the efficacy for solid tumors in the two groups was counted. The tumor control rate, tumor enlargement rate and distant metastasis rate within 1 year of treatment were compared between the two groups, and the survival rate of the two groups of patients within the 1-year period was counted. Results After 1 week and 1 course of treatment, the cortisol levels in the observation group were(318.02 ±17.31) pmol/L and(286.32±13.12) pmol/L respectively, which were lower than those in the control group((585.51 ±22.42) pmol/L and(574.41±21.91) pmol/L respectively)(t=59.776,71.402,all P<0.05).Meanwhile, the complete remission rate in the observation group(57.5%) was higher than that in the control group(27.50%)(χ^(2)=7.366,P<0.001), and the disease progression rate in the control group(7.5%) was significantly lower than that in the control group(30.00%)(χ^(2)=5.251,P<0.05). Within 1 year of treatment, the tumor control rate in the observation group(90.00%) was higher than that in the control group(67.50%)(χ^(2)=4.781,P=0.029<0.05),and the distant metastasis rate in the observation group(2.50%)was lower than that in the control group(25.00%)(χ^(2)=6.746,P=0.009<0.05). During the 1-year follow-up period, there were 10 cases of 1-year death in the observation group, with a survival rate of 7
作者
何媛
邱俊
HE Yuan;QIU Jun(Department of Oncology,Huadu District People′s Hospital of Guangzhou,Guangzhou 510800,China;Department of Oncology,People′s Hospital of Hunan Province,Changsha 410014,China)
出处
《中国现代医生》
2022年第17期87-90,共4页
China Modern Doctor
基金
湖南省科技创新计划项目(2019ZK4026)。
关键词
全身热疗
中晚期结肠癌
应激
肿瘤控制率
生存时间
Whole body hyperthermia
Middle and advanced colon cancer
Stress
Tumor control rate
Survival time
