摘要
目的应用极速脉搏波(ultrafast pulse wave velocity,UFPWV)技术探讨类风湿关节炎(rheumatoid arthritis,RA)患者颈动脉弹性功能及其相关影响因素,为早期防治其动脉硬化提供依据。方法选取120例RA患者作为病例组、60例健康体检者作为对照组进行UFPWV及颈动脉内-中膜厚度(carotid intima-media thickness,cIMT)检查,将病例组分为轻度活动组(A组)和中重度活动组(B组),收集所有受试者的临床指标,对比各组间指标差异,分析各指标与脉搏波速度(pulse wave velocity,PWV)值的相关性。结果(1)各组间PWV值比较:B组高于A组;A组高于对照组[收缩期起始时脉搏波速度(PWV-BS):4.000±0.330 vs 5.590±0.620 vs 7.000±0.430;收缩期结束时脉搏波速度(PWV-ES):5.770±0.890 vs 7.080±0.970 vs 9.150±1.110,P<0.05];(2)RA组BS、ES与年龄、病程、收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、cIMT、类风湿因子(RF)、抗CCP抗体、血沉(ESR)、C反应蛋白(CRP)、血小板(PLT)呈正相关;与25(OH)D_(3)、血红蛋白(Hb)呈负相关(P<0.05)(BS组r=0.500、0.620、0.450、0.320、0.520、0.520、0.500、0.530、0.260、0.520、0.670、0.380、0.380、0.560、-0.410、-0.430。ES组r=0.730、0.730、0.480、0.340、0.580、0.670、0.630、0.570、0.300、0.580、0.800、0.430、0.430、0.670、-0.570、-0.440);(3)RF、抗CCP抗体、年龄、病程、SBP、LDL-C、PLT为RA患者动脉硬化的危险因素;Hb、25(OH)D_(3)为保护因素(P<0.05)。结论UFPWV能早期准确地检测出RA患者动脉的弹性变化,临床可以通过防治某些危险因素来降低RA患者心血管事件的发生。
Objective The carotid elastic function and its influencing factors in rheumatoid arthritis(RA)patients were investigated by ultrafast pulse wave velocity(UFPWV)technique,which can provide evidence for the early prevention and treatment of atherosclerosis.Methods 120 RA patients were selected as the case group and 60 healthy subjects as the control group for UFPWV and carotid intima-media thickness(cIMT)examination,and the case group was divided into mild activity group(group A)and moderate and severe activity group(group B).Clinical indicators of all subjects were collected,the differences of indicators among groups were compared,and the correlation between indicators and PWV values was analyzed.Results(1)PWV value of group B was higher than that of group A.The pulse wave velocity at the beginning of systole in group A was higher than that in the control group,PWV-BS:4.000±0.330 vs 5.590±0.620 vs 7.000±0.430;PWV-ES:5.770±0.890 vs 7.080±0.970 vs 9.150±1.110,(P<0.05);(2)BS and ES in RA group and age,course of disease,systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),cIMT,rheumatoid factor(RF),anti-CCP antibody,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and platelets(PLT)were positively correlated,but was negatively correlated with Hemoglobin,25(OH)D_(3),Hemoglobin(Hb)(P<0.05)(In BS group,r=0.500,0.620,0.450,0.320,0.520,0.520,0.500,0.530,0.260,0.520,0.670,0.380,0.380,0.560,-0.410,-0.430.In ES group,r=0.730,0.730,0.480,0.340,0.580,0.670,0.630,0.570,0.300,0.580,0.800,0.430,0.430,0.670,-0.570,-0.440);(3)RF,anti-CCP antibody,age,course of disease,SBP,LDL-C and PLT were risk factors for atherosclerosis in RA patients.Hb and 25(OH)D_(3) were protective factors(P<0.05).Conclusion UFPWV can accurately detect arterial elasticity changes in RA patients at an early stage,which can reduce cardiovascular events in RA patients by preventing and treating certain risk factors.
作者
李宜函
张爽
马思扬
李玉宏
Li Yihan;Zhang Shuang;Ma Siyang;Li Yuhong(The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000 China)
出处
《锦州医科大学学报》
2022年第3期66-70,共5页
Journal of Jinzhou Medical University
基金
辽宁省兴辽英才计划项目,项目编号:XLYC1802049。
关键词
类风湿关节炎
超声
极速脉搏波
颈动脉弹性
炎症
心血管疾病
rheumatoid arthritis
ultrasound
ultrafast pulse wave velocity
carotid elasticity
inflammation
cardiovascular diseases
