摘要
目的探讨无先兆偏头痛(migraine without aura,MwoA)患者发作间期体素-镜像同伦功能连接(voxel-mirrored homotopic connectivity,VMHC)是否受损,以及针刺治疗后VMHC的变化情况。材料和方法54名MwoA患者和44名匹配的健康对照者被纳入研究。MwoA患者接受了为期4周的针刺治疗,而健康对照组没有任何治疗。收集所有受试者的功能磁共振成像数据和临床资料,比较患者与健康对照组基线、患者针刺治疗前后VMHC的差异。最后探讨针刺调节的脑区VMHC变化与临床评分改善的相关性。结果与对照组相比,MwoA患者双侧小脑Ⅷ区、楔叶和中央后回的VMHC明显降低(体素水平P<0.001,组水平P<0.05)。针刺后,MwoA患者的临床指标明显改善,静息态功能磁共振成像显示双侧楔叶减低的VMHC明显增强(体素水平P<0.001,组水平P<0.05)。双侧楔叶VMHC的增强与焦虑自评量表评分改变呈正相关(r=0.291,P<0.05)。结论双侧小脑、视觉皮层和初级躯体感觉皮层的VMHC受损可能参与了偏头痛发作间期的中枢机制。针刺治疗偏头痛具有显著的临床疗效,并可增强双侧楔叶减弱的VMHC。
Objective:To investigate whether interictal voxel-mirrored homotopic connectivity(VMHC)was impaired in migraine without aura(Mwo A)patients,and how did VMHC change after acupuncture treatment.Materials and Methods:Fifty-four Mwo A patients and matched forty-four healthy controls were recruited into this study.Patients underwent a four-week acupuncture treatment,whereas controls didn’t have any therapy.Functional magnetic resonance imaging data and clinical information were acquired at baseline and after treatment.The VMHC analysis method was used to compare the difference between two groups at baseline and in MwoA patients before and after treatment.Furthermore,correlation analysis was conducted to explore the relationship between VMHC changes of brain regions modulated by acupuncture treatment and improvement in clinical scores.Results:Compared with healthy controls,MwoA patients revealed significantly decreased VMHC in the bilateral cerebellum_Ⅷ,cuneus and postcentral gyrus(voxel level P<0.001,cluster level P<0.05).After acupuncture treatment,the clinical indicators of migraine patients were significantly improved,and resting-state functional magnetic resonance imaging showed that weakened VMHC of the bilateral cuneus remarkably enhanced(voxel level P<0.001,cluster level P<0.05).The change of VMHC in the bilateral cuneus was positively correlated with change of self-rating anxiety scale scores(r=0.291,P<0.05).Conclusions:Impaired VMHC in the bilateral cerebellum,visual cortex and primary somatosensory cortex may be involved in the central mechanism of MwoA during interictal period.Acupuncture treatment had significant clinical efficacy for migraine,and could enhance weaken VMHC in the bilateral cuneus.
作者
张亚男
刘璐
张雅杰
刘大鹏
刘妮
汪振佳
王麟鹏
霍健伟
ZHANG Yanan;LIU Lu;ZHANG Yajie;LIU Dapeng;LIU Ni;WANG Zhenjia;WANG Linpeng;HUO Jianwei(Department of Radiology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Department of Acupuncture and Moxibustion,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Department of Acupuncture and Moxibustion,Shanxi Hospital of Integrated Traditional and Western Medicine,Taiyuan 030001,China;Department of Acupuncture and Moxibustion,Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第6期50-55,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
北京市属医院科研培育项目(编号:PZ2021016)。
关键词
偏头痛
无先兆
发作间期
针刺
功能磁共振成像
体素-镜像同伦功能连接
migraine without aura
interictal period
acupuncture
functional magnetic resonance imaging
voxel-mirrored homotopic connectivity
