摘要
目的:探讨二甲双胍联合屈螺酮炔雌醇片对多囊卵巢综合征(PCOS)不孕症患者糖脂代谢及性激素水平的影响。方法:回顾性分析2019年1月至2020年1月该院收治的84例PCOS不孕症患者的临床资料,按照治疗方法不同将其分为对照组与观察组各42例。对照组采用屈螺酮炔雌醇片治疗,观察组在对照组基础上联合盐酸二甲双胍缓释胶囊治疗,二者均在停用屈螺酮炔雌醇片后,使用氯米芬片进行促排卵治疗。比较两组治疗前、治疗3个月后糖脂代谢指标[空腹血糖(FBG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)]水平、性激素[黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)及雌二醇(E_(2))]水平及停用屈螺酮炔雌醇片半年后的月经恢复正常率、妊娠率。结果:治疗后,两组FBG、FINS、TC、TG水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组LH、FSH、T水平均低于治疗前,E_(2)水平均高于治疗前,且观察组LH、FSH、T水平低于对照组,E_(2)水平高于对照组,差异有统计学意义(P<0.05);观察组月经恢复正常率、妊娠率依次为73.81%(31/42)、54.76%(23/42),分别高于对照组的47.62%(20/42)、26.19%(11/42),差异均有统计学意义(P<0.05)。结论:二甲双胍联合屈螺酮炔雌醇片治疗PCOS不孕症患者,可有效改善糖脂代谢指标和性激素水平,加快月经恢复正常,提高妊娠率,效果优于单用屈螺酮炔雌醇片治疗。
Objective:To explore effects of Metformin combined with Drospirenone and ethinylestradiol tablets on glucose and lipid metabolism and sex hormone levels in infertile patients with polycystic ovary syndrome(PCOS).Methods:The clinical data of the infertile patients with PCOS admitted to our hospital from January 2019 to January 2020 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,42 cases in each.The control group was treated with Drospirenone and ethinylestradiol tablets,while the observation group was treated with Metformin hydrochloride sustained-release capsules on the basis of that of the control group.Both of them were treated with Clomiphene tablets for ovulation induction after discontinuation of Drospirenone and ethinylestradiol tablets.The glucose and lipid metabolism levels[fasting blood glucose(FBG),fasting insulin(FINS),total cholesterol(TC),triacylglycerol(TG)],the sex hormone levels[luteinizing hormone(LH),follicle-stimulating hormone(FSH),testosterone(T)and estradiol(E_(2))],the menstrual return to normal rate and the pregnancy rate after six months of discontinuation of Drospirenone and ethinylestradiol tablets were compared between the two groups.Results:After the treatment,the levels of FBG,FINS,TC and TG in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of LH,FSH,and T in the two groups were lower than those before the treatment,and the levels of E_(2) were higher than those before the treatment;the levels of LH,FSH,and T in the observation group were lower than those in the control group,and the level of E_(2) was higher than that in the control group;and the difference was statistically significant Significance(P<0.05).The menstrual return to normal rate and the pregnancy rate in the observation group were 73.81%(31/42)and 54.76%(23/42),resp
作者
高明娟
GAO Mingjuan(Department of Reproductive Health and Infertility of Yongshan Hospital,Zhoukou 461300 Henan,China)
出处
《中国民康医学》
2022年第11期139-141,145,共4页
Medical Journal of Chinese People’s Health
关键词
二甲双胍
屈螺酮炔雌醇片
多囊卵巢综合征
不孕症
糖脂代谢
性激素
妊娠率
Metformin
Drospirenone and ethinylestradiol tablets
Polycystic ovary syndrome
Infertility
Glucose and lipid metabolism
Sex hormone
Pregnancy rate
