摘要
目的 探讨急性心肌梗死(AMI)合并高血压对其发病昼夜节律的影响。方法 连续收集1006例行急诊经皮冠状动脉介入治疗术(PCI)的AMI病例,根据是否合并高血压分为合并高血压组及未合并高血压组。将1 d以6 h及2 h为单位分为4、12个时间段,分别比较两组在各个时间段的发病例数及组间差异。结果 倾向评分匹配(PSM)后两组在0:00—5:59、6:00—11:59、12:00—17:59和18:00—23:59这4个时间段发病差异均有统计学意义(P=0.014、0.045、0.035、0.016);将时间以2 h为单位进一步细分为12个时间段后,合并高血压组发病时间的清晨高峰为10:00—11:59(P=0.004),且在凌晨2:00—3:59时出现了另一个高峰(P=0.002);多因素Logistic回归提示,AMI合并高血压较未合并高血压相比,清晨时间段(6:00—11:59)发病的风险增加(OR,1.440;95%CI,1.089~1.904;P=0.011)。结论 高血压影响AMI的发病昼夜节律及发病高峰时间,并且是AMI在清晨高峰时间段(6:00—11:59)发病的危险因素。
Objective To investigate the influence of acute myocardial infarction(AMI)combined with hypertension on its circadian rhythm.Methods A total of 1006 cases of AMI who underwent emergency percutaneous coronary intervention(PCI)surgery were collected continuously,and they were divided into a combined hypertension group and a non-combined hypertension group according to whether it was combined with hypertension.The day was divided into 4 and 12 time periods in units of 6 hours and 2 hours,and the number of cases and differences between the two groups in each time period were compared.Results After propensity score matching(PSM),the two groups had different onsets in the 4 time periods of 0:00—5:59,6:00—11:59,12:00—17:59 and 18:00—23:59(P=0.014,0.045,0.035,0.016).After further subdividing the time into 12 time periods in units of 2 hours,the morning peak of the onset time of the hypertensive group was 10:00—11:59(P=0.004),and there was another peak at 2:00—3:59 in the morning(P=0.002).Multivariate Logistic regression indicated that compared with non-combined hypertension,AMI with hypertension had an increased risk of onset in the morning(6:00—11:59)(OR,1.440;95%CI,1.089-1.904;P=0.011).Conclusion Hypertension affects the circadian rhythm of the onset of AMI and the peak time of onset,and it is a risk factor for the onset of AMI in the morning peak period(6:00—11:59).
作者
马良
米合尔古丽·吐尔逊太
刘敏敏
梁亚
门丽影
栾晓倩
李南方
严治涛
Ma Liang;Miheerguli·Turxuntai;Liu Minmin;Liang Ya;Men Liying;Luan Xiaoqian;Li Nanfang;Yan Zhitao(School of Medicine, Shihezi University, Shihezi 832000;Dept of Cardiovascular Internal Medicine,The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi 832008;Dept of General Medicine, Yili Friendship Hospital, Yining 835000;Institute of Hypertension, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001)
出处
《安徽医科大学学报》
CAS
北大核心
2022年第6期982-986,共5页
Acta Universitatis Medicinalis Anhui
基金
国家重点研发计划课题(编号:2018YFC1311503)。
关键词
急性心肌梗死
高血压
昼夜节律
acute myocardial infarction
hypertension
circadian rhythm
