摘要
以紫香1号百香果为研究对象,通过分析百香果水提物皮肤应用的安全性,为百香果的开发利用提供毒理学依据。分别对大鼠和家兔进行急性经皮毒性实验、单次皮肤刺激性实验、多次皮肤刺激性实验及急性眼刺激性实验。结果表明,经急性经皮毒性实验后所有大鼠均未出现死亡及明显的中毒症状;经单次皮肤刺激性实验后,家兔和大鼠皮肤未形成明显红斑和水肿,皮肤刺激强度为无刺激;经多次皮肤刺激性实验后大鼠给药皮肤出现少量局部红斑,但5 d后恢复正常,综合评分皮肤刺激强度为无刺激;经眼刺激实验后,家兔角膜、虹膜均未出现明显异常,眼刺激强度为无刺激。因此,百香果水提物对大鼠和家兔皮肤和眼均无毒性和明显刺激性。
Taking Zixiang No.1 passion fruit as the research object,the safety of skin application of water extract of passion fruit was analyzed to provide toxicological basis for the development and utilization of passion fruit.Acute percutaneous toxicity test,single skin irritation test,multiple skin irritation test and acute eye irritation test were performed on rats and rabbits respectively.The results showed that none of the rats died or had obvious poisoning symptoms after acute percutaneous toxicity test.After a single skin irritation test,the skin of rabbits and rats did not form obvious erythema and edema,and the intensity of skin irritation was no irritation.After repeated skin irritation experiments,the skin of rats showed a small amount of local erythema,but returned to normal 5 days later,and the comprehensive score of skin irritation intensity was no irritation.After eye stimulation experiment,there were no obvious abnormalities in cornea and iris,and the intensity of eye stimulation was non-stimulation.Therefore,the water extract of passion fruit had no toxicity and obvious irritation to the skin and eyes of rats and rabbits.
作者
方晓彤
杨虹
王宇
周俊良
FANG Xiaotong;YANG Hong;WANG Yu;ZHOU Junliang(Institute of Pomology Science,Guizhou Provincial Academy of Agricultural Sciences,Guiyang 550025,China;School of Basic Medicine,Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China)
出处
《现代食品》
2022年第12期180-183,共4页
Modern Food
基金
贵州省科技计划项目(黔科合服企〔2019〕4002、黔科合服企〔2021〕8号、黔科合支撑〔2022〕一般150)。
关键词
百香果水提物
皮肤安全性评价
眼刺激性实验
passion fruit water extract
skin safety evaluation
eye irritation test
