摘要
艾滋病以CD4细胞进行性减少和慢性炎症紊乱为特征。细胞焦亡是一种重要的调节性死亡方式,参与艾滋病疾病进展。在ART时代,HIV-1感染已经变成了一种慢性疾病,如何在ART的基础上开发新的疗法实现病毒库清除,达到艾滋病的功能性治愈是当前的研究热点,新近研究表明焦亡可以诱导感染细胞发生死亡,可能能够清除HIV-1病毒库,为艾滋病功能性治愈提供了潜在干预策略。本文将对细胞焦亡在HIV-1感染中的作用及其发生机制进行综述。
AIDS is characterized by progressive loss of CD4 cells and chronic inflammation.Pyroptosis is a kind of regulated cell death and involves in the progression of AIDS.In the era of ART,HIV-1 infection has changed from a lethal condition to a chronic disease.The current research focuses on how to further develop novel therapies to eliminate the latent reservoir and achieve a functional cure for AIDS.Recent studies have shown that pyroptosis can induce the death of infected cells,which might be used to eliminate the HIV-1 latent reservoir.It provides a potential intervention strategy toward a functional cure of AIDS.In this review,the role of pyroptosis in HIV-1 infection and the underlying mechanism have been summarized.
作者
王酉源
胡伟
张超
王福生
WANG Youyuan;HU Wei;ZHANG Chao;WANG Fusheng(Medical School of Chinese PLA,Beijing l00853,China;National Clinical Research Center for Infectious Diseases,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2022年第6期735-740,共6页
Chinese Journal of Aids & STD
基金
北京大学临床科学家计划(BMU2019LCKXJ013)
解放军总医院“优秀青年科学基金”培育专项(2019-YQPY-009)
国家自然科学基金(81901617)。
