摘要
目的 建立本实验室孕中晚期正常妊娠妇女纤溶抗凝相关指标的参考区间.方法 收集孕期22~41周的孕中晚期无妊娠并发症的正常妊娠妇女374例,分为22~27周组(125例)、28~34周组(127例)和35~41周组(122例)三个亚组;同时正常非孕妇女(120例)作为对照组.检测纤维蛋白原(Fg)、D-二聚体(D-D)、纤维蛋白原降解产物(FDP)、抗凝血酶III(AT-Ⅲ)和蛋白S(PS)活性并分析其在各组间的变化,按亚组建立上述指标的医学参考值区间.结果 与对照组比较,妊娠各亚组的Fg、D-D、FDP水平均明显升高,AT-Ⅲ活性降低(P<0.01),PS活性则明显下降(P<0.001).各亚组间比较,三组间Fg结果随孕期增加而增高,差异有统计学意义(P<0.02),三组比较D-D、FDP结果随孕期增加而增高,差异有统计学意义(P<0.001),AT-Ⅲ活性在各组间差异无统计学意义(P>0.05),PS在22~27周组分别与28~34周组、35~41周组比较差异有统计学意义(P<0.02).孕中晚期正常妊娠妇女的Fg、D-D、FDP的95%参考区间:22~27周组分别为2.51~4.97 g/L,≤2.52 mg/L FEU,≤10.39 mg/L;28~34周组分别为2.67~5.21 g/L,≤3.67 mg/L FEU,≤12.08 mg/L;35~41周组分别为2.85~5.55 g/L,≤4.34 mg/L FEU,≤13.27 mg/L.PS 95%参考区间分别为:22~27周组25.7~57.9%,≥28周组21.6~55.4%.结论 在孕中晚期不同阶段,孕妇Fg、D-D、FDP升高、而PS活性则明显降低,本实验室初步建立无妊娠并发症妊娠妇女的参考区间.
Objective To establish reference intervals for fibrinolysis and anti-coagulation of normal pregnant women at second and third gestational ages of laboratory.Methods A total of 374 normal pregnant women with no pregnancy complications in the second and third trimesters of pregnancy during 22~41 weeks were collected and divided into 22-27 weeks group(125 cases),28-34 weeks group(127 cases)and 35-41 weeks group(122 cases),while normal non-pregnant women(120 cases)served as the control group.Fibr-inogen(Fg),D-dimer(D-D),fibrinogen degradation products(FDP),activity of antithrombin-Ⅲ(AT-Ⅲ),protein S(PS)were measured and analyzed,and establish reference intervals at subgroups of pregnant women.Results Compared with control group,the levels of Fg,D-D and FDP in each pregnancy subgroup were significantly increased,the activity of AT-Ⅲ was decreased(P<0.01),and the activity of PS was significantly decreased(P<0.001).Compared among subgroups,Fg was increased with the progress o pregnancy and the difference was stistically significant(P<0.02).D-D and FDP were increased with the progress of pregnancy and the differences were statistically significant(P<0.001),there was no signifcant difference in AT-Ⅲ activity among the groups(P>0.05),and there were statistically significant differences in PS between the 22-27 week group,the 28-34 week group and the 35-41 week group,respectively(P<0.02).The 95%reference intervals of normal pregnant women at second and third gestational ages for Fg,D-D,FDP:at 22~27 weeks group were 2.51~4.97 g/L,≤2.52 mg/L FEU,≤10.39 mg/L,respectively.At 28~34 weeks group were 2.67~5.21 g/L,≤3.67 mg/L FEU,≤12.08 mg/L,respectively.At 35~41 group were 2.85-~5.55 g/L,≤4.34 mg/L FEU,≤13.27 mg/L,respectively.The 95%reference intervals of PS:at 22~27 weeks group was 25.7~57.9%,at≥28 wees group was 21.6~55.4%,espectively.Conclusion Fg,D-D,FDP are significantly higher,but PS is significantly lower in normal pregnant women at second and third gestational ages.Our laboratory preliminarily establis
出处
《浙江临床医学》
2022年第5期757-759,共3页
Zhejiang Clinical Medical Journal
关键词
纤溶
抗凝
妊娠妇女
参考区间
Fibrinolysis
Anticoagulation
Pregnancy
Reference intervals
