摘要
目的 分析体液免疫及细胞免疫功能检测对梅毒的诊断价值。方法 选取90例梅毒患者作为研究组,另选取90例健康体检者作为参照组。两组均进行体液免疫及细胞免疫功能检测,比较两组体液免疫功能指标[免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)]和细胞免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、NK细胞)水平。结果 研究组一、二、三期梅毒IgG、IgA、IgM及CD8^(+)水平均高于参照组, CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK细胞水平均低于参照组,差异有统计学意义(P<0.05);二期梅毒IgG(16.59±4.20)mg/dl、IgA(3.75±0.48)mg/dl、IgM(1.89±0.39)mg/dl及CD8^(+)(28.71±3.19)%均高于一期梅毒的(13.45±2.15)mg/dl、(3.36±0.43)mg/dl、(1.56±0.27)mg/dl、(24.71±3.00)%, CD3^(+)(60.98±2.56)%、CD4^(+)(32.56±3.88)%、CD4^(+)/CD8^(+)(1.16±0.23)%、NK细胞(16.23±2.69)%低于一期梅毒的(63.00±2.77)%、(35.14±3.10)%、(1.30±0.20)、(18.62±2.00)%,潜伏期梅毒IgG、IgA、IgM及CD8^(+)水平低于一期梅毒和二期梅毒, CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK细胞水平均高于一期梅毒和二期梅毒,差异有统计学意义(P<0.05)。结论 体液免疫及细胞免疫功能检测在临床上可对梅毒进行诊断,保证患者疾病的及时良好干预,实现疾病症状的明显缓解,同时还可以判断梅毒的严重程度,进一步为患者后期治疗提供指导意见。
Objective To analyze the diagnostic value of humoral and cellular immune function tests in patients with syphilis.Methods 90 syphilis patients were selected as the research group,and another 90 healthy subjects were selected as the reference group.Thehumoral and cellular immune function were detected in both groups,and the humoral immune function indexes[immunoglobulin G(IgG),immunoglobulin A(IgA),and immunoglobulin M(IgM)]and cellular immune function indexes(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),NK cells)were compared between the two groups.Results The levels of IgG,IgA,IgM and CD8^(+)in the primary,secondary and tertiary syphilis in the research group were higher than those in the reference group,while the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and NK cells in the research group were lower than those in the reference group.All the differences were statistically significant(P<0.05).The IgG(16.59±4.20)mg/dl,IgA(3.75±0.48)mg/dl,IgM(1.89±0.39)mg/dl and CD8^(+)(28.71±3.19)%of secondary syphilis were higher than(13.45±2.15)mg/dl,(3.36±0.43)mg/dl,(1.56±0.27)mg/dl,(24.71±3.00)%of primary syphilis,while the CD3^(+)(60.98±2.56)%,CD4^(+)(32.56±3.88)%,CD4^(+)/CD8^(+)(1.16±0.23)%,NK cells(16.23±2.69)%of secondary syphilis were lower than(63.00±2.77)%,(35.14±3.10)%,(1.30±0.20),(18.62±2.00)%of primary syphilis;the levels of IgG,IgA,IgM and CD8^(+)of latent syphilis were lower than those of primary and secondary syphilis,while the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and NK cells were higher than those of primary and secondary syphilis.All the differences were statistically significant(P<0.05).Conclusion Humoral and cellular immune function tests can be used clinically to diagnose syphilis,ensure timely and good intervention of the patient's disease,significantly alleviate the symptoms of the disease,and also determine the severity of syphilis,thus providing guidance for the patient's later treatment.
作者
马驰
MA Chi(Shenyang Anning Hospital,Shenyang 110164,China)
出处
《中国实用医药》
2022年第13期66-68,共3页
China Practical Medicine
关键词
体液免疫
细胞免疫
梅毒
梅毒螺旋体
Humoral immunity
Cellular immunity
Syphilis
Treponema pallidum
