摘要
胎儿生长受限(FGR)是产科常见并发症,其病因及发病机制至今尚未完全阐明,常为多种因素共同作用的结果,可导致多种不良妊娠结局,包括胎儿宫内窘迫、胎死宫内、低出生体重儿、早产、新生儿窒息等,还可引起儿童体格、智力发育异常及成年后的代谢综合征、心血管疾病、糖尿病等。因妊娠期不易对其做出诊断,多为产后确诊。为早诊断、早干预,改善FGR预后,降低母胎不良结局,近年来有不少研究倾向于对FGR的预测,尤其是胎盘及母体血清中相关因子的异常表达,相关因子主要包括血管内皮生长因子、胎盘生长因子、胰岛素样生长因子、妊娠相关血浆蛋白A、血管生成素以及基质金属蛋白酶-9,本文对具有该疾病预测作用的相关因子进行归纳综述。
Fetal growth restriction(FGR)is a common obstetric complication,the etiology and pathogenesis of which have not yet been fully elucidated,and is often the result of a combination of multiple factors.FGR may lead to a variety of adverse pregnancy outcomes,including fetal intrauterine distress,intrauterine fetal death,low birth weight infants,preterm birth,neonatal asphyxia,etc.It can also cause abnormal physical and intellectual development in childhood and metabolic syndrome,cardiovascular disease and diabetes in adulthood.FGR is not easy to be diagnosed during pregnancy and is mostly diagnosed after delivery.In order to diagnose and intervene early,improve the prognosis of FGR and reduce the adverse maternal-fetal outcomes.In recent years,many studies tend to predict FGR,especially the abnormal expression of related factors in placenta and maternal serum.And these related factors are mainly vascular endothelial growth factor,placental growth factor,insulin-like growth factor,pregnancy-associated plasma protein A,angiopoietin,and matrix metalloproteinase-9.This paper summarizes and reviews factors that can be used to predict this disease.
作者
毛冰昆
吴雪
姜亚倩
卢克新
MAO Bingkun;WU Xue;JIANG Yaqian;LU Kexin(Department of Obstetrics,Binzhou Medical University Hospital,Shandong,Binzhou 256600,China)
出处
《中国医药科学》
2022年第11期72-75,共4页
China Medicine And Pharmacy
关键词
胎儿生长受限
预测作用
相关因子
妊娠
Fetal growth restriction
Predictive role
Associated factors
Pregnancy
