摘要
目的:分析慢性阻塞性肺疾病(COPD)患者病情的严重程度与其血清B型钠尿肽(BNP)、高敏C反应蛋白(hs-CRP)、生长分化因子-15(GDF-15)水平及红细胞分布宽度(RWD)的相关性。方法:选取2019年1月至2019年12月在贵阳市第二人民医院接受治疗的80例COPD患者和同期在该院接受体检的50例健康体检者作为研究对象。根据80例COPD患者病情时期的不同将其分别作为急性组(入院时病情处于急性加重期)和稳定组(经治疗病情稳定后)。将50例健康体检者作为正常对照组。对比三组人员血清BNP、hs-CRP、GDF-15的水平及RWD。对急性组患者的病情进行GOLD分级,对比不同分级患者血清BNP、hs-CRP、GDF-15的水平及RWD。分析急性组患者血清BNP、hs-CRP、GDF-15的水平及RWD与其GOLD分级的相关性。结果:(1)急性组患者血清hs-CRP、BNP、GDF-15的水平及RWD均显著高于稳定组患者和正常对照组体检者,P<0.05。(2)急性组患者中GOLD分级为4级患者血清BNP、hs-CRP、GDF-15的水平、RDW均显著高于GOLD分级为1级、2级、3级的患者,P<0.05。GOLD分级为3级患者血清BNP、hs-CRP、GDF-15的水平、RDW均显著高于GOLD分级为1级、2级的患者,P<0.05。GOLD分级为2级患者血清BNP、hs-CRP、GDF-15的水平、RDW均显著高于GOLD分级为1级的患者,P<0.05。(3)进行Speaman相关性分析的结果显示,急性组患者血清hs-CRP、BNP、GDF-15的水平及RWD与其GOLD分级均呈正相关。结论:随着COPD患者病情的加重,其血清BNP、hs-CRP、GDF-15的水平及RWD均呈升高的趋势。COPD患者病情的严重程度与其血清BNP、hs-CRP、GDF-15的水平及RDW均呈正相关。
Objective:To analyze the correlation between the severity of chronic obstructive pulmonary disease(COPD)and the levels of B-type natriuretic peptide(BNP),high-sensitivity C-reactive protein(HS-CRP),growth differentiation factor-15(GDF-15)and red blood cell distribution width(RWD).Methods:A total of 80 COPD patients who received treatment in Guiyang Second People’s Hospital from January 2019 to December 2019 and 50 healthy subjects who received physical examination in guiyang Second People’s Hospital during the same period were selected as the research objects.According to the different stages of COPD,80 patients were divided into acute group(acute exacerbation stage at admission)and stable group(stable condition after treatment).Fifty healthy subjects were selected as the normal control group.The levels of BNP,Hs-CRP,GDF-15 and RWD in serum of the three groups were compared.The patients in the acute group were graded with GOLD,and the levels of BNP,Hs-CRP,GDF-15 and RWD in serum of patients with different grades were compared.The levels of BNP,Hs-CRP and GDF-15 in serum and the correlation between RWD and GOLD grade in acute group were analyzed.Results:(1)The levels of hSCRP,BNP,GDF-15 and RWD in acute group were significantly higher than those in stable group and normal control group,P<0.05.(2)In acute group,the levels of BNP,Hs-CRP,GDF-15 and RDW of GOLD grade 4 patients were significantly higher than those of GOLD grade 1,2 and 3 patients,P<0.05.The levels of BNP,HS-CRP,GDF-15 and RDW of GOLD grade 3 patients were significantly higher than those of GOLD grade 1 and 2 patients,P<0.05.The levels of BNP,HS-CRP,GDF-15 and RDW of GOLD grade 2 patients were significantly higher than those of GOLD grade 1 patients,P<0.05.(3)Speaman correlation analysis showed that the levels of hS-CRP,BNP,GDF-15 and RWD were positively correlated with GOLD grade in acute group.Conclusion:With the exacerbation of COPD patients,the levels of BNP,Hs-CRP,GDF-15 and RWD in serum all show an increasing trend.The severity of COPD patien
作者
代颖
杨丽秋
陈雪英
DAI Ying;YANG Liqiu;CHEN Xueying(Department of Respiratory and Critical Care,The Second People’s Hospita l of Guiyang,Guiyang 550000,China)
基金
贵州科技计划项目,编号:筑科合同[20161001]02号。
关键词
血清B型钠尿肽
高敏C反应蛋白
慢性阻塞性肺疾病
GOLD分级
相关性
Serum B-type natriuretic peptide
High sensitivity C-reactive protein
Chronic obstructive pulmonary disease
GOLD grade
The correlation
