摘要
目的:探讨血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平与良性前列腺增生(BPH)伴组织学炎症之间的关系。方法:收集2018年1月至2021年3月于广东医科大学附属佛山高明医院术后病理诊断为BPH伴组织学炎症的93例患者作为研究对象,纳入观察组,术后诊断为单纯BPH患者31例纳入对照组,比较两组患者的血清TNF-α、IL-6水平及前列腺体积(PV)差异,分析观察组患者TNF-α和IL-6与PV关系;观察组进一步根据炎症严重程度分为轻度组、中度组和重度组,各31例,比较三组TNF-α、IL-6和PV差异,并分析上述指标与炎症严重程度的关系。结果:观察组患者的血清TNF-α、IL-6水平和PV均显著高于对照组,差异具有统计学意义(P<0.05)。观察组血清TNF-α和IL-6水平与PV均呈正相关(r=0.341,P=0.000;r=0.612,P=0.000)。血清TNF-α、IL-6水平和PV均为重度组>中度组>轻度组,组间两两比较的差异均具有统计学意义(P<0.05)。血清TNF-α、IL-6水平及PV与炎症严重程度呈显著正相关(r=0.385,P=0.000;r=0.554,P=0.000;r=0.632,P=0.000)。结论:血清TNF-α和IL-6水平与BPH伴组织学炎症之间存在密切关系,即TNF-α和IL-6水平越高,PV越大,伴组织学炎症越严重。
Objective To investigate the relationship between serum tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)levels and benign prostatic hyperplasia(BPH)with histological inflammation.Methods A total of 93 patients with BPH and histological inflammation diagnosed by postoperative pathology in Foshan Gaomin Hospital Affiliated to Guangdong Medical University from January 2018 to March 2021 were included in the observation group,and 31 patients with BPH alone diagnosed by postoperative pathology were included in the control group.The levels of serum TNF-αand IL-6 and prostate volume(PV)in the two groups were compared,and the relationship between TNF-αand IL-6 and PV in the observation group was analyzed.The observation group was further divided into mild group,moderate group and severe group according to the severity of inflammation,with 31 cases in each group.The differences of TNF-α,IL-6 and PV in the three groups were compared,and the relationship between the above indexes and the severity of inflammation were analyzed.Results The serum TNF-α,IL-6 levels and PV in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Serum TNF-αand IL-6 levels were positively correlated with PV in the observation group(R=0.341,P=0.000;R=0.612,P=0.000).The results of comparison of the levels of TNF-α,IL-6 and PV in serum were severe group>moderate group>mild group,and the pairwise comparison between the two groups,with statistical significance(P<0.05).Serum TNF-α,IL-6 and PV levels were positively correlated with the severity of inflammation(R=0.385,P=0.000;R=0.554,P=0.000;P=0.632,P=0.000).Conclusion There is a close relationship between serum TNF-αand IL-6 levels and BPH with histological inflammation,namely,the higher the levels of TNF-αand IL-6,the larger the PV and the more severe the histological inflammation.
作者
熊永高
彭丽红
解绪红
刘小真
XIONG Yong-gao;PENG Li-hong;XIE Xu-hong;LIU Xiao-zhen(Foshan Gaoming District People's Hospital Affiliated to Guangdong Medical University,Guangdong Foshan 528500)
出处
《深圳中西医结合杂志》
2022年第6期10-13,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
佛山市卫生和计生局医学科研项目(20180419)。
