摘要
目的:探究与观察糖尿病肾病患者血小板活化状态与微炎症因子及肾血流指标的关系。方法:选取2019年8月-2020年10月的80例糖尿病肾病患者为A组,同时期的80例糖尿病无并发症患者为B组,80名体检健康者为C组。检测与比较三组的血小板活化状态指标(CD41、CD61、CD62p)、微炎症因子(CRP、IL-6、TNF-α)及肾血流指标(肾段动脉Vmax、Vmin、RI),比较A组中不同分期者的血小板活化状态指标、微炎性因子及肾血流指标,Pearson相关性分析血小板活化状态指标与微炎性因子及肾血流指标的关系。结果:A组的血小板活化状态指标、微炎症因子水平均显著高于B、C组,B组均显著高于C组,差异均有统计学意义(P<0.05)。A组的RI显著高于B、C组,B组显著高于C组(P<0.05),A组的Vmax、Vmin均显著低于B、C组,B组均显著低于C组(P<0.05)。A组中不同分期者的血小板活化状态指标、微炎症因子水平及肾血流指标比较,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,血小板活化状态指标与微炎症因子及肾血流指标均有密切关系(P<0.05)。结论:糖尿病肾病患者的血小板活化状态与微炎症因子及肾血流均呈现异常状态,且之间有密切的关系,因此在糖尿病肾病患者中的检测价值较高。
Objective:To explore and observe the relationship between platelet activation state and microinflammatory factors and renal blood flow index in patients with diabetic nephropathy.Method:A total of 80 diabetic nephropathy patients from August 2019 to October 2020 were selected as group A,80 diabetic patients without complications during the same period were selected as group B,and 80 healthy subjects were selected as group C.The platelet activation state indexs(CD41,CD61,CD62p),microinflammatory factors(CRP,IL-6,TNF-α)and renal blood flow indexs(renal artery Vmax,Vmin,RI)in the three groups were detected and compared,the platelet activation state indicators,microinflammatory factors and renal blood flow indicators in the different stages of group A were compared,Pearson correlation analysis of platelet activation status index,microinflammatory factors and renal blood flow index.Result:Platelet activation state index,microinflammatory factor level in group A were significantly higher than those in group B and C,and group B were significantly higher than those in group C,the differences were statistically significant(P<0.05).RI in group A was significantly higher than that in group B and C,and group B was significantly higher than that in group C(P<0.05).Vmax and Vmin in group A were significantly lower than those in group B and C,and group B were significantly lower than those in group C(P<0.05).Comparison of platelet activation status indicators,levels of microinflammatory factors and renal blood flow indicators in group A with different stages,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that platelet activation state indexs was closely related to microinflammatory factors and renal blood flow index(P<0.05).Conclusion:Platelet activation state and inflammatory factors and renal blood flow in diabetic nephropathy patients show abnormal state,and there is a close relationship between them,therefore,the detection value is higher in patients with diabetic nephropathy.
作者
曾晓敏
ZENG Xiaomin(Zhongxiang Hospital of Traditional Chinese Medicine,Hubei Province,Zhongxiang 431900,China)
出处
《中国医学创新》
CAS
2022年第17期42-46,共5页
Medical Innovation of China
关键词
糖尿病肾病
血小板活化状态
微炎症因子
肾血流
疾病分期
Diabetic nephropathy
Platelet activation state
Microinflammatory factors
Renal blood flow
Stages of disease
