摘要
目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并原发性高血压(EH)患者中医体质类型特点。方法将86例OSAHS合并EH患者根据睡眠呼吸暂停低通气指数(AHI)结果分为3组,轻度组15例,中度组25例,重度组46例。通过中医四诊、中医体质问卷调查判定体质类型,测定其体质量指数(BMI)、血压、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FPG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、室间隔厚度(IVST)、左心室后壁厚度(LVPWT)、左心室射血分数(LVEF),并计算左心室质量(LVM)、体表面积、左心室质量指数(LVMI),并研究体质类型与检测指标之间的关系。结果①中度组AHI高于轻度组(P<0.05),重度组AHI高于轻度组、中度组(P<0.05)。重度组BMI高于轻度组(P<0.05)。中度组吸烟指数高于轻度组(P<0.05)。重度组HDL-C水平低于轻度组(P<0.05)。②偏颇体质中痰湿质最多,共69次,占体质频数33.82%(69/204),且不同年龄段分层患者及性别均以痰湿质类型最多。重度组痰湿质、气虚质类型比例高于中度组、轻度组(P<0.05)。③中度组LVEF低于轻度组(P<0.05)。④多元线性回归分析显示,BMI为痰湿质的影响因素。结论OSAHS合并EH与代谢综合征、心功能下降相关,吸烟是其危险因素,痰湿质是OSAHS合并EH患者的主要体质,BMI为痰湿质的危险因素。
Objective To investigate Chinese Medical Constitutions patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and essential hypertension(EH).Methods Totally 86 OSAHS patients combined with EH were divided into three groups including mild OSAHS group(n=15),moderate OSAHS group(n=25),and severe OSAHS group(n=46)according to apnea hypopnea index(AHI).The constitution types were investigated by questionnaire.The key observation was body mass index(BMI),blood pressure,total cholesterol(TC),triglyceride(TG),fasting blood glucose(FPG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),uric acid(UA),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),left ventricular ejection fraction(LVEF),and left ventricular mass(LVM),body surface area(BSA),left ventricular mass index(LVMI);and the correlation between body type and detection indicators was studied.Results The AHI in the severe group was the highest among the three groups,followed by the moderate group and the mild group(all P<0.05).The BMI in the severe group was higher than that in the mild group(P<0.05).The smoking index in the moderate group was higher than that in the mild group(P<0.05).The level of HDL-C in the severe group was lower than that in the mild group(P<0.05).Phlegm-dampness constitution was the most prevalent in constitutions with 69 cases,accounting for 33.82%(69/204)of the total constitution,and the distribution of phlegm-dampness constitution was the most common in patients with different age groups and genders.The proportions of constitution(phlegm-dampness and qi-deficiency)in the severe group were higher than the other groups(P<0.05).The LVEF in the moderate group was lower than that in the mild group(P<0.05).Multiple linear regression analysis showed that BMI was the influencing factor of phlegm-dampness.Conclusion OSAHS complicated with EH has a positive effect on metabolic
作者
黄晓佳
顾宁
包伟
HUANG Xiaojia;GU Ning;BAO Wei(GCP Office,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210022;Department of Cardiovascular Medicine,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210022)
出处
《河北中医》
2022年第3期397-401,424,共6页
Hebei Journal of Traditional Chinese Medicine
基金
第二批江苏省中医药领军人才培养项目(苏中医科教〔2018〕4号)。
