摘要
目的总结肝移植术后早期移植物功能不全(early allograft dysfunction,EAD)预测指标的研究进展。方法查阅近年来国内外有关肝移植术后EAD预测指标研究的相关文献并进行综述。结果肝移植术后EAD与患者预后及长期生存密切相关。近年来不断有研究报道血清尿酸、中性粒细胞与淋巴细胞比率、血管性血友病因子与蛋白C比率、血清脑钠肽、细胞因子、透明质酸、可溶性CD163、脂质、血清乳酸、凝血因子Ⅴ、血清磷等新型血清标志物用来早期发现与识别肝移植术后EAD的发生与发展,使肝移植后EAD早期有效的干预成为可能。结论肝移植术后EAD的早期识别与预防尤为重要,虽然目前已经有研究提出一些新型预测指标来预测肝移植术后EAD的发生,但相关研究仍较少,仍有很多亟待解决的问题,未来需要更多更进一步的研究来验证这些新型指标在临床中的运用价值。
Objective To summarize the research progress of early allograft dysfunction(EAD)predictors after liver transplantation.Method The literatures about the studies of predictive predictors of EAD after liver transplantation in recent years were reviewed.Results The EAD was closely related to the prognosis and long-term survival of patients.In recent years,there were some reports of serum uric acid,neutrophil and lymphocyte ratio,von Willebrand factor to protein C ratio,serum brain natriuretic peptide,cytokine,hyaluronic acid,soluble CD163,serum lipid,lactic acid,coagulation factorⅤ,serum phosphorus etc.new serum biomarkers for early detection and recognition the occurrence and development of the EAD after liver transplantation.It was possible to intervene EAD early and effectively after liver transplantation.Conclusions Early recognition and prevention of EAD after liver transplantation is particularly important.Although some new predictive indicators have been proposed to predict occurrence of EAD after liver transplantation,relevant studies are lesser and there are still many problems to be solved.Further studies will be conducted to verify clinical application value of these new indicators.
作者
苏洋
丁佑铭
SU Yang;DING Youming(Department of Hepatobiliary Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2022年第6期829-834,共6页
Chinese Journal of Bases and Clinics In General Surgery
关键词
肝移植
早期移植物功能不全
预测指标
liver transplantation
early allograft dysfunction
predictor
