摘要
目的探讨脑血栓患者血清中Dickkopf相关蛋白1(DKK-1)、骨硬化蛋白(SOST)水平与疾病严重程度的关系。方法选取110例脑血栓患者为脑血栓组,并根据严重程度分为轻、中、重度组;另选取同期一般资料相匹配的健康体检者110例为对照组。检测血清中DKK-1、SOST水平变化,并进行相关性分析;采用受试者工作特征(ROC)曲线分析DKK-1、SOST诊断重度脑血栓的效能。结果脑血栓组血清DKK-1、SOST水平高于对照组,差异有统计学意义(P<0.05);轻度组、中度组、重度组血清中DKK-1、SOST的水平呈显著升高趋势(P<0.05)。血清DKK-1与SOST水平存在正相关性(r=0.705,P<0.05),血清DKK-1、SOST水平均与脑血栓患者美国国立卫生研究院卒中量表(NIHSS)评分呈正相关性(r=0.625,r=0.674,P<0.05)。DKK-1、SOST诊断重度脑血栓的曲线下面积(AUC)分别为0.879(95%CI:0.808~0.950)、0.815(95%CI:0.710~0.919);DKK-1联合SOST诊断的AUC为0.911(95%CI:0.849~0.973)。结论脑血栓患者血清中DKK-1、SOST表达水平增高,且与疾病严重程度密切相关。DKK-1联合SOST对重度脑血栓有较高的诊断效能,对二者水平进行监测有助于评估患者疾病严重程度。
Objective To explore the relationships of levels of Dickkopf-related protein 1(DKK-1)and sclerostin(SOST)in serum with disease severity in patients with cerebral thrombosis.Methods A total of 110 patients with cerebral thrombosis were selected as cerebral thrombosis group,and they were divided into mild,moderate and severe groups according to their severity;in addition,110 healthy subjects with matching general data were selected as control group.Serum DKK-1 and SOST levels were detected and their correlation was analyzed.Receiver operator characteristic(ROC)curve was used to analyze the efficacy of DKK-1 and SOST in diagnosing severe cerebral thrombosis.Results The levels of DKK-1 and SOST in the cerebral thrombosis group were significantly higher the control group(P<0.05);the serum levels of DKK-1 and SOST in severe,moderate and mild groups showed an significantly increasing trend(P<0.05).There was a positive correlation between serum DKK-1 and SOST level(r=0.705,P<0.05);the serum DKK-1 and SOST levels were positively correlated with National Institutes of Health Stroke Scale(NIHSS)score of patients with cerebral thrombosis(r=0.625,r=0.674,P<0.05).The area under the curve(AUC)of DKK-1 and SOST in the diagnosis of severe cerebral thrombosis was 0.879(95%CI,0.808 to 0.950)and 0.815(95%CI,0.710 to 0.919),respectively;the AUC of DKK-1 combined with SOST was 0.911(95%CI,0.849 to 0.973).Conclusion The levels of serum DKK-1 and SOST in patients with cerebral thrombosis are high and closely related to the severity of the disease.DKK-1 combined with SOST has a high diagnostic efficiency for severe cerebral thrombosis.Monitoring the levels of DKK-1 and SOST is helpful to evaluate the severity of the patient′s disease.
作者
王伟伟
徐家萍
贾军辉
张浩亮
WANG Weiwei;XU Jiaping;JIA Junhui;ZHANG Haoliang(Neonatal Intensive Care Unit,Xianyang Hospital of Yan′an University,Xianyang,Shaanxi,712000)
出处
《实用临床医药杂志》
CAS
2022年第11期67-70,75,共5页
Journal of Clinical Medicine in Practice
