摘要
Metronidazole(MTZ)loaded Eudragit S-100(ES-100)nonwoven nanofbrous mats were successfully electrospun and evaluated for intestinal drug delivery.MTZ was varied in the range of 1–15%(w/w)in ES-100 nanofbrous mats,the morphological characterization of nanofbrous mats was carried out using FE-SEM and the average diameter of nanofber was found in the range 150–600 nm.WAXD and DSC demonstrated the amorphous nature of MTZ in ES-100 nanofbrous mats.Their contact angle analysis confrmed the hydrophobic nature.The mechanical strength of ES-100 nanofbrous mats decreased with increasing MTZ concentration.The drug release profles showed 74%MTZ release from ES-100d within 2 h at pH 6.8 which is the colonic environment.Antibacterial activities against gram-positive bacteria(Staphylococcus aureus)and gramnegative bacteria(Escherichia coli)showed that the ES-100 nanofbrous mats loaded with MTZ exhibited good activity.
基金
Ms.Priyanka P.Rade gratefully acknowledges the Department of Science and Technology,New Delhi,India for the award of DST-INSPIRE fellowship(IF160594)for her doctoral research
The authors also gratefully acknowledge LIA MATSUCAT,France for the collaboration
The authors express their heartfelt gratitude to Evonik Industries,Mumbai,India,for providing Eudragit S 100 as a gift sample.
