摘要
糖尿病已成为一种严重危害人类健康的慢性疾病,并给社会经济带来了巨大负担。糖尿病患者的足部溃疡由于其原发病糖尿病本身引起的肢体远端缺血、感染、神经病变等导致患者先天愈合条件不足,创面难以及时修复,由此增加了感染相关死亡与截肢的风险。传统治疗方法以截肢为主,不利于患者维持较高的生活质量,因而间充质干细胞疗法治疗糖尿病足正引起越来越多学者的关注。该文阐述了近年来间充质干细胞治疗糖尿病足溃疡的机制、临床前与临床研究方面的研究进展。
Diabetes has become a chronic disease endangering people’s health all over the world.This translated into a huge economic burdento society.Diabetic foot ulcer is difficult to heal due to ischemia,infection,neuropathy and other reasons,which leads to increased risk of amputation and infectious death.Amputation is the main method in traditional treatment,which is adverse to improve the quality of patients’lives.Thus,more and more scientists pay attention to the treatment of diabetic foot with mesenchymal cells.In this article,we will give a general introduction to the multi-functional mesenchymal stromal cells and explain the mechanism of their use in diabetic foot ulcer,as well as introduce several cases of clinical and preclinical studies on the application of mesenchymal cells in the treatment of diabetes ulcers in foreign countries.
作者
刘心语
赵廷睿
张墨根
翟朝晖
李玉莉
Liu Xinyu;Zhao Tingrui;Zhang Mogen;Zhai Zhaohui;Li Yuli(School of Clinical Medicine,Weifang Medical University,Weifang 261053,China;School of Rehabilitation Medicine,Weifang Medical University,Weifang 261053,China;Institution of Plastic Surgery,Weifang Medical University,Weifang 261053,China)
出处
《中华整形外科杂志》
CSCD
2021年第12期1404-1409,共6页
Chinese Journal of Plastic Surgery
基金
山东省自然科学基金重点项目(ZR2020KE018)
山东省高等学校科技计划项目(J17KA253)
山东省医药卫生科技发展计划(2018WS062)
潍坊市科技发展计划(2020YX040)。
关键词
糖尿病足
伤口愈合
糖尿病
间充质干细胞
Diabetic foot
Wound healing
Diabetes mellitus
Mesenchymal stromal cells
