摘要
目的:观察冠心宁片联合西药治疗稳定型心绞痛的效果以及对血管内皮功能及炎症反应的影响。方法:纳入64例稳定型心绞痛患者,按照随机数字表法分为治疗组和对照组各32例。2组患者均予常规西药治疗,治疗组加服冠心宁片治疗。2组均连续治疗8周。比较2组患者治疗前后每周的心绞痛发作次数、每次发作持续时间、每周的硝酸甘油用量,于治疗前及治疗8周后检测一氧化氮(NO)、内皮素(ET)-1、肿瘤坏死因子(TNF)-α及超敏C-反应蛋白(hs-CRP)水平。结果:治疗后,2组每周心绞痛发作次数、硝酸甘油用量均较治疗前减少,每次发作持续时间均较治疗前缩短,差异均有统计学意义(P<0.01)。治疗组每周心绞痛发作次数、硝酸甘油用量均少于对照组,每次发作持续时间短于对照组,差异均有统计学意义(P<0.01)。2组血浆NO水平均较治疗前升高,ET-1水平均较治疗前下降,差异均有统计学意义(P<0.01);治疗组NO水平高于对照组,ET-1水平低于对照组,差异均有统计学意义(P<0.01)。2组血清TNF-α、hs-CRP水平均较治疗前下降(P<0.01);治疗组2项指标值均低于对照组(P<0.01)。结论:在常规西药治疗基础上加用冠心宁片治疗稳定型心绞痛可提高疗效,有效改善患者的心绞痛发作情况和血管内皮功能,减轻炎症反应程度。
Objective:To observe the effect of Guanxinning tablets combined with western medicine on stable angina pectoris and the effect on vascular endothelial function and inflammatory response.Methods:A total of 64 cases of patients with stable angina pectoris were enrolled and divided into the treatment group and the control group according to the random number table method,with 32 cases in each group.Both groups were treated with routine western medicine,and the treatment group was additionally treated with Guanxinning tablets.Both groups were treated for eight weeks.Before and after treatment,the numbers of weekly angina pectoris attacks per week,the duration of each attack and the dosage of nitroglycerin were compared.Before treatment and after eight-week treatment,the levels of nitric oxide(NO),endothelin(ET)-1,tumor necrosis factor(TNF)-αand hypersensitive C-reactive protein(hs-CRP)were detected.Results:After treatment,the numbers of angina pectoris attacks per week and the dosage of nitroglycerin per week in the two groups were reduced when compared with those before treatment,and the duration of each attack was shortened,differences being significant(P<0.01).The number of angina pectoris attacks per week and the dosage of nitroglycerin per week in the treatment group were fewer than those in the control group,and the duration of each attack was shorter,differences being significant(P<0.01).Plasma NO levels in the two groups were increased when compared with those before treatment,and ET-1 levels were decreased,differences being significant(P<0.01);NO level in the treatment group was higher than that in the control group,and ET-1 level was lower,differences being significant(P<0.01).The levels of TNF-αand hs-CRP in serum in the two groups were decreased when compared with those before treatment(P<0.01);the above two indexes in the treatment group were lower than those in the control group(P<0.01).Conclusion:Based on routine western medicine treatment,the additional application of Guanxinning tablets for stable
作者
铁春苗
易昌容
TIE Chunmiao;YI Changrong
出处
《新中医》
CAS
2022年第10期74-77,共4页
New Chinese Medicine
关键词
稳定型心绞痛
冠心宁片
血管内皮功能
炎症反应
Stable angina pectoris
Guanxinning tablets
Vascular endothelial function
Inflammatory response
