摘要
铁死亡是一种铁依赖性的细胞死亡形式,其特征是细胞内脂质过氧化物积累和氧化还原失衡。与其他细胞死亡模式相比,铁死亡表现出特定的生物学和形态学特征。谷胱甘肽过氧化物酶4(GPX4)的脂质过氧化物修复活性丧失、氧化还原活性铁的存在以及含有多不饱和脂肪酸(PUFA)的磷脂氧化被认为是铁死亡的明显特征。本综述报道了常见急性或慢性肝脏疾病谱中的铁死亡,并讨论铁死亡治疗原发性肝癌最常见病理类型肝细胞癌的方法。
Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance.Ferroptosis shows specific biological and morphological features when compared to other cell death patterns.The loss of lipid peroxide repair activity by glutathione peroxidase 4(GPX4),the presence of redox-active iron and the oxidation of polyunsaturated fatty acid(PUFA)-containing phospholipids are considered as distinct fingerprints of ferroptosis.In this review,we report the contribution of ferroptisis to the spectrum of acute or chronic liver diseases.Finally,we discuss the use of ferroptosis as a therapeutic approach against hepatocellular carcinoma,the most common pathological type of primary liver cancer.
作者
刘思嘉
张喜玲
黄翠君
刘云建
Liu Sijia;Zhang Xiling;Huang Cuijun;Liu Yunjian(Department of Anesthesiology,Jiujiang University Affiliated Hospital,Jiujiang 332001,China;Infusion Center,Heze Municipal Hospital,Heze 274000,China;Medical Examination Center,Jiujiang No.1 People’s Hospital,Jiujiang 332005,China;Department of Hepatobiliary Surgery,Jiujiang University Affiliated Hospital,Jiujiang 332001,China)
出处
《中华普通外科学文献（电子版）》
CAS
2022年第3期231-235,共5页
Chinese Archives of General Surgery(Electronic Edition)
基金
江西省自然科学基金面上项目(20202BABL206092)
江西省教育厅科学技术研究项目(GJJ161064)。
关键词
铁死亡
细胞死亡
肝脏
铁代谢
Ferroptosis
Cell death
Liver
Iron metabolism
