摘要
脓毒症是指炎症状态下宿主反应失调导致的器官功能障碍,已经成为临床危重症患者的主要死亡原因之一,但目前的治疗局限于积极治疗原发病以及对症治疗,对其病理过程尚缺乏有效遏制手段。越来越多的证据显示,维生素C可从多条途径影响脓毒症以及随之而来的脓毒性休克和多器官功能障碍病理过程。多个有关脓毒症模型的动物实验以及临床研究表明,及时补充足量维生素C对病情发展有显著影响。
Sepsis was defined as organ dysfunction caused by a dysregulated host response to infection,which has become one of the leading causes of death of clinical critically ill patients.However,the current treatment is only limited to active treatment of primary disease and symptomatic treatment.There is still a lack of effective means to contain the process.A growing body of evidence suggests that vitamin C,a physiological reductant,influences sepsis and the subsequent pathological process of septic shock and multiple organ dysfunction through multiple pathways.A variety of animal experiments and clinical studies on sepsis models have shown that timely and adequate vitamin C supplementation has a significant effect on the progression of the disease.
作者
贺丽玲
闫新明
HE Liling;YAN Xinming(Emergency Department,Bethune Hospital,Shanxi Medical University,Tongji Shanxi Hospital,Taiyuan 030000,China)
出处
《医药导报》
CAS
北大核心
2022年第7期1004-1007,共4页
Herald of Medicine
