摘要
2021年6月,欧洲心脏病学会发布了《共识文件:心力衰竭调整药物治疗的患者特征》(简称《共识》)。《共识》指出,虽然目前指南推荐明确,证据充分,但心力衰竭的治疗效果仍然不佳。这是由于多数患者用药剂量不足,究其原因主要与血压低、心率慢、肾功能不全或高钾血症相关。《共识》确定9种可能与射血分数降低心力衰竭患者治疗相关的特征,根据患者特征调整指南指导的药物治疗,可以使每例患者比传统最大限度调整疗法获得更好、更全面的治疗。相比2021年4月加拿大心血管学会和加拿大心力衰竭学会联合发布的《心力衰竭指南更新:定义新的射血分数降低心力衰竭药理学标准》,《共识》更侧重于根据不同患者特征进行个性化治疗建议。该文对《共识》进行解读,以期为我国心力衰竭患者的药物治疗提供参考。
In June 2021,the European Society of Cardiology released Patient profiling in heart failure for tailoring medical therapy.A consensus document of the Heart Failure Association of the European Society of Cardiology.The consensus points out that despite guideline recommendations and available evidence,implementation of treatment for heart failure(HF)is poor.The majority of patients have not prescribed drugs at target doses,which is mainly related to low blood pressure,slow heart rate,impaired renal function,or hyperkalaemia.The consensus identified nine profiles that may be relevant for treatment implementation in HF patients with a reduced ejection fraction,adjusted guideline-directed medical therapy to patient profiles,may allow to achieve a better and more comprehensive therapy for each patient than the traditional forced titration therapy.Compared with the heart failure guidelines update:defining a new pharmacological standard of care for heart failure with reduced ejection fraction jointly issued by the Canadian Cardiovascular Society and the Canadian Heart Failure Society in April 2021,this consensus focuses on personalized treatment suggestions according to the different patient profile.This paper interprets the consensus to provide a reference for the medical therapy of HF patients in China.
作者
韩丽珠
尹琪楠
边原
黄雪飞
雷洋
唐凌茜
童荣生
HAN Lizhu;YIN Qinan;BIAN Yuan;HUANG Xuefei;LEI Yang;TANG Lingxi;TONG Rongsheng(Department of Pharmacy & Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Provincial People's Hospital/Affiliated Hospital,University of Electronic Science and Technology of China,Sichuan Academy of Medical Sciences,Chengdu 610072,China)
出处
《医药导报》
CAS
北大核心
2022年第7期937-941,共5页
Herald of Medicine
基金
国家重点研发计划(2020YFC2005506)
个体化药物治疗四川省重点实验室开放课题(2021ZD01)
四川省干部保健科研课题(川干研2021-226)
四川省医学会静脉血栓栓塞症防治专项科研课题(2019HR02)。
关键词
心力衰竭
指南指导药物治疗
临床特征
心率
血压
慢性肾病
心房颤动
Heart failure
Guideline-directed medical therapy
Clinical profiles
Heart rate
Blood pressure
Chronic kidney disease
Atrial fibrillation
