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右美托咪定复合氟比洛芬酯应用于经皮椎间孔镜手术的临床效果与安全性分析 被引量:1

Clinical Effect and Safety Analysis of Dexmedetomidine Combined with Flurbiprofen Axetil in Percutaneous Transforaminal Surgery
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摘要 目的探讨经皮椎间孔镜手术患者使用右美托咪定复合氟比洛芬酯治疗的效果。方法方便选取2019年6月—2021年2月期间该院收治的80例经皮椎间孔镜手术患者为研究对象,根据随机抛硬币方式分为常规组(40例)和研究组(40例)。常规组使用右美托咪定进行治疗,研究组使用右美托咪定复合氟比洛芬酯进行治疗,观察患者不良反应、镇静情况和疼痛程度。结果研究组穿刺定位、神经根刺激、摘取髓核、手术完成各时段的疼痛评分分别为(1.36±0.62)分、(3.49±0.93)分、(2.39±0.21)分、(0.39±0.23)分;穿刺定位、神经根刺激、摘取髓核、手术完成各时段的镇静评分(2.88±0.66)分、(3.29±0.88)分、(2.98±0.12)分、(2.54±0.38)分优于常规组,差异有统计学意义(t=4.419、3.525、3.619、9.599、3.616、4.451、3.474、4.299,P<0.05)。研究组和常规组不良反应发生率分别为7.50%、10.00%,两组比较差异无统计学意义(χ^(2)=0.000,P=1.000)。结论为经皮椎间孔镜手术患者使用右美托咪定复合氟比洛芬酯进行治疗,可以改善患者镇静、疼痛情况,且不会增加不良反应,麻醉效果显著,安全性高,临床应用价值较高。 Objective To investigate the effect of dexmedetomidine combined with flurbiprofen axetil in patients un⁃dergoing percutaneous transforaminal surgery.Methods A total of 80 patients with percutaneous transforaminal sur⁃gery who were admitted to the hospital from June 2019 to February 2021 were convenienthy selected as the research objects,and they were divided into a routine group(40 cases)and a study group(40 cases)according to random coin tossing.The patients in the routine group were treated with dexmedetomidine,and the patients in the study group were treated with dexmedetomidine combined with flurbiprofen axetil.The adverse reactions,sedation,and pain in⁃tensity were observed.Results The pain scores of the patients in the study group in each period of puncture position⁃ing,nerve root stimulation,extraction of nucleus pulposus,and completion of surgery were(1.36±0.62)points,(3.49±0.93)points,(2.39±0.21)points,and(0.39±0.23)points,respectively,the sedation scores of patients in the study group at each time period of puncture positioning,nerve root stimulation,extraction of nucleus pulposus,and comple⁃tion of surgery were(2.88±0.66)points,(3.29±0.88)points,(2.98±0.12)points,(2.54±0.38)points were better than the routine group,the difference was statistically significant(t=4.419,3.525,3.619,9.599,3.616,4.451,3.474,4.299,P<0.05).The incidence of adverse reactions in the study group and routine group were 7.50%and 10.00%,re⁃spectively,and there was no statistically significant difference between the two groups(χ^(2)=0.000,P=1.000).Conclusion Dexmedetomidine combined with flurbiprofen axetil for patients undergoing percutaneous transforaminal surgery can improve sedation and pain.And it will not increase adverse reactions,the anesthesia effect is remarkable,the safety is high,and the clinical application value is high.
作者 王磊 隋玉国 杨振 肖义荣 WANG Lei;SUI Yuguo;YANG Zhen;XIAO Yirong(Department of Anesthesiology,the 907th Hospital of the Joint Logistics Support Force of the Chinese People's Lib-eration Army,Nanping,Fujian Province,353000 China)
出处 《中外医疗》 2022年第16期79-82,87,共5页 China & Foreign Medical Treatment
关键词 右美托咪定 复合 氟比洛芬酯 经皮椎间孔镜 镇痛 镇静 Dexmedetomidine Compound Flurbiprofen axetil Percutaneous transforaminal endoscopy Analgesia Sedation
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