摘要
近年来, 免疫系统在组织再生过程中的调节作用愈发受到重视, 但其具体机制仍未完全阐明。组织再生需要平衡的免疫反应, 尤其是巨噬细胞(MΦ)的极化平衡, 以构建有利于组织再生的局部微环境。该综述总结了MΦ在组织再生性修复中的关键作用, 包括清除细胞碎片、调控干细胞或前体细胞的增殖分化, 促进血管生成等, 并介绍MΦ在干细胞疗法及组织工程技术中的实际应用, 以期为深入探寻免疫细胞对干细胞微环境的影响及基于干细胞的组织工程与再生医学进一步的临床转换提供参考。
The regulatory effect of the immune system during tissue regeneration is gaining more and more attention,yet the underlying mechanisms remain unclear.Tissue regeneration requires a balanced immune response,especially the balanced polarization of macrophages(MΦ),to induce a conducive local microenvironment for tissue regeneration.In this review,the crucial effects of MΦin tissue regeneration are summarized,including the elimination of cell debris,regulation of stem cell proliferation and differentiation,promotion of angiogenesi.In addition,the practical applications of MΦin stem cell therapy and tissue engineering are introduced,in the hope of providing references for further exploration of the effect of immune cells on the stem cell niche,as well as the clinical translation of stem cell-based tissue engineering and regenerative medicine.
作者
张郭
汪振星
孙家明
Zhang Guo;Wang Zhenxing;Sun Jiaming(Department of Plastic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《中华整形外科杂志》
CSCD
2022年第5期588-594,共7页
Chinese Journal of Plastic Surgery
基金
国家重点研发计划(2019YFA0110500)
国家自然科学基金(81873941)。
关键词
再生医学
巨噬细胞
免疫调控
干细胞
干细胞微环境
Regenerative medicine
Macrophages
Immunomodulation
Stem cell
Stem cell niche
