摘要
开发具有成骨诱导的骨填充材料是促进骨再生的重要研究方向。自组装多肽水凝胶凭借其高度的仿生人工细胞外基质结构、低免疫原性、易于合成及修饰、载药灵活等优势为骨组织修复提供了一个高效治疗手段。本文讨论了自组装多肽水凝胶的设计原则,报道了自组装多肽结构特征及组装机制,重点介绍了自组装多肽骨修复水凝胶在递送干细胞、血管内皮细胞、骨形成蛋白、成骨因子以及小分子化合物等方面的最新研究进展,总结了限制自组装多肽水凝胶发展的瓶颈和未来发展方向,为构建高成骨性能凝胶递送系统提供理论参考。
The development of osteoinductive bone-filling biomaterials for bone regeneration is of great significance.Self-assembled peptide hydrogels with high biomimetic extracellular matrix structure,low immunogenicity,easy synthesis and modification,and flexible loading capacity provide a highly efficient therapeutic platform for bone tissue repair.Herein,we discuss the design principles of self-assembled peptide hydrogels,report the structural characteristics and assembly mechanisms of self-assembled peptides,and highlight recent advances in selfassembled peptide hydrogels for bone regeneration,including delivery to cells,bone morphogenetic proteins,active factors and small molecular substances.Finally,the bottleneck and development direction of self-assembled peptide hydrogels are pointed out,aiming to provide guidance for the construction of hydrogel delivery systems with high osteogenic properties.
作者
徐柳
徐姗
相堂永
沙政舟
张键
陈志鹏
XU Liu;XU Shan;XIANG Tangyong;SHA Zhengzhou;ZHANG Jian;CHEN Zhipeng(College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2022年第3期356-364,共9页
Journal of China Pharmaceutical University
基金
国家自然科学基金资助项目(No.82173992)
江苏省研究生科研与实践创新资助项目(No.KYCX_201491)。
关键词
自组装
多肽
骨修复
水凝胶
生物材料
self-assembly
peptide
bone reparation
hydrogel
biomaterials
