摘要
随着仿生化技术的发展,越来越多的体外模型被应用于模拟人体生理和病理过程。这些体外模型可以解决一些科学问题,例如,实时地、可视化地研究药物作用等。器官芯片作为一种体外模型,为基础科学和应用科学提供了新型的手段和方法。而血管化器官芯片作为一种特殊的器官芯片,能更好地模拟人体血管的结构和功能。本文概括了不同血管化器官芯片的结构和功能,分析了血管化器官芯片在模拟生理和病理过程中的应用,讨论了血管化器官芯片作为一种新型体外模型的优势与待解决的问题。最后,对血管化器官芯片的应用前景提出了设想与展望。
With the development of biomimetic technology,more and more in vitro models are used to simulate human physiological and pathological processes.These in vitro models can solve some scientific problems,such as studying drug effects in real-timely and visually.As an in vitro model,organ-on-a-chip provides novel means and methods for basic and applied science.The vascularized organ-on-a-chip,as a special kind of organ-on-achip,can better simulate the structure and function of human blood vessels.In this review,we summarized the structure and function of different vascularized organ-on-a-chip,analyzed the application of vascularized organon-a-chip in simulating physiological and pathological processes,and discussed the advantages and problems to be solved of vascularized organ-on-a-chip as a new in vitro model.Finally,the application of vascularized organon-a-chip is proposed.
作者
刘宏婷
吉晓轩
李菁
孙敏捷
LIU Hongting;JI Xiaoxuan;LI Jing;SUN Minjie(Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2022年第3期264-272,共9页
Journal of China Pharmaceutical University
关键词
器官芯片
血管系统
血管再生和血管发生
生理和病理模型
organ-on-a-chip
vascular system
angiogenesis and vasculogenesis
physiological and pathological model
