摘要
背景:基于Micro-CT微有限元可以研究骨小梁在载荷下的力学响应,通常认为在动物骨小梁标本上骨体积分数是决定骨小梁抗压缩能力的最重要指标,但在微有限元模型中,导致应力集中或决定最大应力的骨微结构指标尚不明确。目的:探究影响骨小梁微有限元模型最大应力的骨微结构指标。方法:获取10只正常大鼠双侧股骨干骺端感兴趣区域骨小梁微观结构指标,比较双侧感兴趣区域骨小梁差异性;构建20个骨小梁微有限元模型并对模型进行加载,以微有限元模型中应力值最大的前5%,2%,1%,0.5%个单元的应力平均值作为最大应力值,根据模型应力、应变验证模型的真实可靠性;最后,以最大应力值为因变量,感兴趣区域骨小梁微观结构指标为自变量,通过多元线性逐步回归法挖掘影响骨小梁微有限元模型最大应力的关键影响因素。结果与结论:双侧股骨干骺端感兴趣区域骨小梁微结构存在同质性(P> 0.05),进而对数据进行合并;20个骨小梁微有限元模型平均单元数232813,节点数60682;前5%,2%,1%,0.5%个单元应力平均值分别为31.91,41.96,50.86,61.23MPa,平均有效应变为3.28%;多元线性逐步回归分析结果提示骨小梁结构模型指数是影响骨小梁微有限元模型最大应力的最重要的骨微结构指标(P <0.001,R^(2)=0.807)。提示:骨小梁结构模型指数是影响骨小梁微有限元模型应力集中的最重要骨微结构指标,骨小梁结构模型指数值越大,杆状骨小梁越多,应力集中范围越大。
BACKGROUND:The mechanical response of trabecular bone under loading can be studied using micro-CT based micro-finite element.It is generally considered that bone volume fraction in animal specimens is the most important index that determines the compressive strength of trabecular bone.However,in the micro-CT based finite element model,the microstructural index leading to stress concentration or determining the maximum stress is not clear.OBJECTIVE:To investigate the microstructural indexes that affect the maximum stress of trabecular bone mic ro-finite element model.METHODS:The microstructural indexes of trabecular bone of 10 normal rats from bilate ral femoral metaphysis region of interest were obtained and the differences of trabecular bone in bilateral regions of inte rest were compared.The 20 trabecular bone finite element models were constructed and loaded.The average stress values of the ranking 5%,2%,1% and 0.5% of stress value were taken as the maximum stress value.The reliability of the models was verified according to the stress and effective strain.Finally,with the maximum stress value as the dependent variable and the trabeculae microstructural index as the independent variable,the key factor affecting the maximum stress of trabeculae micro-finite element model was explored by multiple linear stepwise regression method.RESULTS AND CONCLUSION:There was homogeneity in trabecular bone microstructure of bilateral femoral metaphysis(P> 0.05),and then data were combined.The average number of elements and nodes of 20 trabeculae finite element models was 232 813 and 606 82.The average stress of the ranking 5%,2%,1% and 0.5% elements was 31.91,41.96,50.86 and 61.23 MPa,respectively,and the average effective strain was 3.28%.The results of multiple linear stepwise regression analysis indicated that the structure model index was the most important factor influencing the maximum stress of trabeculae finite element model(P <0.001,R^(2)=0.807).It is indicated that the trabecular bone structure model index is the mo
作者
钟毅征
黄培镇
蔡群斌
郑利钦
何兴鹏
董航
Zhong Yizheng;Huang Peizhen;Cai Qunbin;Zheng Liqin;He Xingpeng;Dong Hang(Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China;First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China;First Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China Zhong Yizheng,Doctoral candidate,Attending physician,Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China Corresponding author:Dong Hang,MD,Associate chief TCM physician,First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第9期1313-1318,共6页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金青年科学基金项目(82004390),项目负责人:董航。
关键词
骨小梁
骨微结构
最大应力
应力集中
有限元
生物力学
骨小梁结构模型指数
trabecular bone
microstructure
maximum stress
stress concentration
finite element
biomechanics
trabecular bone structure model index
