摘要
目的探讨温阳健脾益肺固本方对比常规中医辨证论治治疗慢性湿疹的近期和远期疗效及安全性。方法选取2019年9月—2020年12月北京中医药大学东直门医院收治的肺脾失调型慢性湿疹患者86例为研究对象,随机分为观察组和对照组各43例。观察组予温阳健脾益肺固本中药系列协定处方治疗,对照组予段行武教授门诊常规中医辨证治疗,2组均治疗12周,随访1年。观察比较2组患者治疗前和治疗4周后、12周后的湿疹严重程度[湿疹面积及严重度指数(EASI)]、瘙痒程度[视觉模拟评分(VAS)]、生活质量[皮肤病生活质量指数(DLQI)]、实验室指标及临床疗效、起效时间、复发率、复发次数、安全性。结果2组患者治疗4周、12周后的EASI评分、VAS评分、DLQI评分、EOS计数及2组治疗12周后的总IgE水平、对照组治疗4周后的总IgE水平均明显低于治疗前(P均<0.05),但2组治疗12周后上述各指标及总有效率比较差异均无统计学意义(P均>0.05);对照组治疗4周后的EASI评分、总IgE水平明显低于观察组(P均<0.05),总有效率明显高于观察组(P<0.05),整体起效时间明显短于观察组(P<0.05);在随访期内,观察组的复发率为15.15%(5/33),低于对照组的38.24%(13/34),差异有统计学意义(P<0.05),2组复发次数比较差异无统计学意义(P>0.05)。2组治疗期间均未发生不良反应。结论温阳健脾益肺固本系列方对符合肺脾不足型的慢性湿疹治疗效果确切,尤其在降低复发率方面表现出了优势,且用药安全性良好。
Objective It is to explore the short-term and long-term efficacy and safety of Wenyang Jianpi Yifei Guben decoction compared with conventional traditional Chinese medical syndrome differentiation and treatment in the treatment of chronic eczema.Methods A total of 86 patients with chronic eczema of lung and spleen disorder type who were admitted to Dongzhimen Hospital of Beijing University of Chinese Medicine from September 2019 to December 2020 were selected as the research objects,and they were randomly divided into the observation group and the control group with 43 cases in each group.The observation group was treated with a series of traditional Chinese medicines for warming yang,strengthening the spleen,nourishing the lungs and strengthening the body according to the prescribed prescription,while the control group was treated with routine syndrome differentiation in the outpatient clinic of Professor DUAN Xingwu.Both groups were treated for 12 weeks and followed up for 1 year.The severity of eczema[Eczema Area and Severity Index(EASI)],the degree of pruritus[visual analogue scale(VAS)],and the quality of life[dermatology life quality index(DLQI)]and laboratory indicators before treatment and after 4 weeks and 12 weeks of treatment,and clinical efficacy,onset time,recurrence rate,number of recurrences,and safety were observed and compared between the two groups.Results The EASI score,VAS score,DLQI score,EOS count after 4 weeks and 12 weeks of treatment and total IgE level after 12 weeks of treatment of the two groups,and the total IgE level after 4 weeks of treatment of the control group were significantly lower than those before treatment(all P<0.05),but there was no significant difference in the above indexes and total effective rate between the two groups after 12 weeks of treatment(all P>0.05).The EASI score and total IgE level after 4 weeks of treatment in the control group were significantly lower than those in the observation group(all P<0.05),but the total effective rate was significantly higher and
作者
张梦鸽
徐菁
陈彦蓉
王凯利
刁若涵
祝佳音
段行武
ZHANG Mengge;XU Jing;CHEN Yanrong;WANG Kaili;DIAO Ruohan;ZHU Jiayin;DUAN Xingwu(Beijing University of Chinese Medicine,Beijing 100029,China;Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《现代中西医结合杂志》
CAS
2022年第10期1342-1346,1368,共6页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
国家中医药管理局中医药行业科研专项(2015468001)。
关键词
慢性湿疹
肺脾失调
温阳健脾益肺固本方
常规中医辨证
chronic eczema
lung and spleen disorders
warming yang,strengthening the spleen,benefiting the lung and strengthening the body
conventional TCM syndrome differentiation
