摘要
目的 探索影响中药治疗晚期食管癌患者的预后因素。方法 选取72例Ⅳ期食管癌患者进行分析,并根据生存时间定义中药治疗优势人群及劣势人群。单因素分析采用Log-rank检验,证候要素与预后分组间的相关性采用秩和检验,多因素分析采用Cox比例风险模型。结果 72例食管癌患者的中位生存期是17.9个月。单因素分析结果显示,是否脏器转移、是否肺转移、治疗后症状自评及中药用药时长与中药治疗晚期食管癌预后有关。对中医证候要素与生存期预后分组间的秩和检验显示,证候要素气滞同样可能是影响预后的因素之一。多因素分析结果显示,中药用药时长因素是影响中药治疗晚期食管癌预后的独立因素。结论 中药用药时长影响中药治疗晚期食管癌的患者预后。
Objective To explore the prognostic factors that affect patients with advanced esophageal cancer treated with Traditional Chinese medicine(TCM).Methods A total of 72 patients with stage IV esophageal cancer were selected for analysis, and the advantaged and disadvantaged groups of TCM treatment were defined according to survival time. The log-rank method was used for the univariate analysis, the rank-sum test was used for the correlation between the syndrome type and the prognostic grouping, and the Cox proportional risk model was used for multiple factors.Results The median survival of the 72 patients with esophageal cancer was 17.9 months. The univariate analysis of the result showed that the presence of organ metastasis, the presence of lung metastasis, and the post-treatment symptom self-assessment and length of herbal medication were related to the prognosis of advanced esophageal cancer treated with TCM. The rank-sum test between the TCM syndrome elements, and survival prognosis grouping showed that the syndrome element of Qi stagnation may also affect prognosis. The result of the multifactorial analysis showed that the factor of the duration of the TCM administration was an independent factor that affects the prognosis of advanced esophageal cancer treated with TCM.Conclusion The duration of TCM treatment affected the prognosis of patients with advanced esophageal cancer.
作者
陈佳阳
刘婷婷
周睿
刘剑
易丹辉
侯丽
徐钰莹
吴朝旭
冯利
CHEN Jiayang;LIU Tingting;ZHOU Rui;LIU Jian;YI Danhui;HOU Li;XU Yuying;WU Chaoxu;FENG Li(National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 101121,China;Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China;School of Statistics,Renmin University of China,Beijing 100872,China;The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2022年第5期446-451,共6页
Journal of Beijing University of Traditional Chinese Medicine
基金
首都卫生发展科研专项重点攻关项目(No.2016-1-4171)。
关键词
食管癌
晚期食管癌
中医药
优势人群
生存期
预后因素分析
esophageal cancer
advanced esophageal cancer
traditional Chinese medicine
advantaged population
survival
prognostic factor analysis
