摘要
目的研究合并肌少症的晚期非小细胞肺癌患者的临床病理特征,评估肌少症对晚期非小细胞肺癌患者无进展生存期(PFS)和总生存期(OS)的影响。方法选择2017年6月—2019年12月期间我院收治的112例Ⅲb期~Ⅳ期非小细胞肺癌患者,根据骨骼肌指数(SMI)将患者分为合并肌少症组(64例)和未合并肌少症组(48例)。所有患者采用电话或门诊随访,比较两组患者的PFS及OS;采用Cox回归分析晚期非小细胞肺癌预后危险因素。结果合并肌少症组的PFS、OS均低于未合并肌少症组(P<0.05)。多因素Cox风险比例回归分析显示肌少症、T分期是晚期非小细胞肺癌患者PFS的独立影响因素(P<0.05),肌少症、淋巴结转移是影响晚期非小细胞肺癌患者OS的独立危险因素(P<0.05)。结论治疗前合并肌少症的晚期非小细胞肺癌患者PFS及OS均低于未合并肌少症者,治疗前合并肌少症可能作为晚期非小细胞肺癌患者预后评估的指标。
Objective The objective of this study was to determine the clinicopathological characteristics of advanced non-small cell lung cancer patients with sarcopenia,and to evaluate the effect of sarcopenia on progression-free survival(PFS)and overall survival(OS)in advanced non-small cell lung cancer patients.Methods A total of 112 patients with stage IIIb-IV non-small cell lung cancer who were treated in our hospital from June 2017 to December 2019 were selected,and the patients were divided into the sarcopenia group(64 cases)and the non-sarcopenia group(48 cases).All patients were followed up by telephone or outpatient service.PFS and OS between the two groups were compared.Cox regression was used to analyze the prognostic risk factors of advanced non-small cell lung cancer.Results The survival rates of PFS and OS in the group with sarcopenia were lower than those in the group without sarcopenia(P<0.05).Multivariate Cox hazard proportional regression analysis showed that sarcopenia and T stage were independent risk factors for PFS in patients with advanced non-small cell lung cancer(P<0.05);sarcopenia and lymph node metastasis were independent risk factors for OS in patients with advanced non-small cell lung cancer(P<0.05).Conclusion The PFS and OS of advanced non-small cell lung cancer patients with sarcopenia are lower than those of non-sarcopenic patients,sarcopenia may be used as a prognostic indicator for advanced non-small cell lung cancer patients.
作者
张浩
杨新官
何涌
ZHANG Hao;YANG Xinguan;HE Yong(Department of Radiation Oncolocy,The Second Affiliated Hospital of Guilin Medical University,Guilin 541000,China;Department of Radiation Oncolocy,Guilin People′s Hospital)
出处
《实用肿瘤学杂志》
CAS
2022年第3期214-219,共6页
Practical Oncology Journal
基金
广西自然科学基金项目(编号:2018GXNSFAA281080)。
关键词
肌少症
晚期非小细胞肺癌
病理特征
危险因素
预后
Sarcopenia
Advanced non-small cell lung cancer
Pathological features
Risk factors
Prognosis
