摘要
年龄相关性黄斑变性(AMD)是严重影响视力的一种眼底疾病,其病因与发病机制尚未明确,可能与环境因素、代谢和遗传等因素相关。目前,有研究表明,肠道微生物群直接或间接与AMD相关。因此,检测和调控人体的肠道微生物群可能会为AMD的诊断和治疗提供新的诊疗思维。本文汇总了近年来相关研究,并对预防和治疗AMD的可能诊治方法,如粪便微生物移植、补充益生元和益生菌、饮食调整及抗生素和免疫球蛋白治疗进行概述。
Age-related macular degeneration(AMD)is a fundus disease that seriously affects vision.Its etiology and pathogenesis are not clear,but may be related to environment,metabolism,and genetics.At present,studies have shown that intestinal microbiota is directly or indirectly related to AMD.Therefore,the detection and regulation of human intestinal microbiota may provide new ideas for diagnosis and treatment of AMD.This paper summarizes the relevant research in recent years and outlines the possible methods for the prevention and treatment of AMD,such as fecal microbial transplantation,probiotic supplement,diet adjustment,antibiotics,and immunoglobulin.
作者
张园园
王天宇
白建豪
薛雅文
彭清
ZHANG Yuanyuan;WANG Tianyu;BAI Jianhao;XUE Yawen;PENG Qing(School of Medicine,Tongji University,Shanghai 200331,China;Department of Ophthalmology,Shanghai Tenth People’s Hospital,Shanghai 200072,China)
出处
《眼科新进展》
CAS
北大核心
2022年第6期491-494,共4页
Recent Advances in Ophthalmology
基金
国家自然科学基金项目(编号81470029)
《促进市级医院临床技能与临床创新三年行动计划》关键支撑项目(编号SHDC2020CR5014)。
关键词
年龄相关性黄斑变性
肠道微生物群
菌群失调
age-related macular degeneration
intestinal microbiota
dysbacteriosis
