摘要
目的:系统评价中西医结合防治老年髋部骨折患者深静脉血栓(DVT)的有效性。方法:计算机检索知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Cochrane Library、Web of Science。检索自建库至2021年5月17日,搜集所有关于中西医结合组对比单纯西医组防治老年髋部骨折患者深静脉血栓的随机对照试验(RCT)研究,由2位研究者独立筛选文献,提取资料,并根据Cochrane偏倚风险指标进行质量评价,采用RevMan 5.4软件进行Meta分析。结果:共纳入20篇文献,1714例患者。Meta分析结果显示:中西医结合组DVT的发生率为[RR=0.19,95%CI(0.11,0.32),P<0.001];D-二聚体水平[SMD=-1.59,95%CI(-2.09,-1.09),P<0.001]、血小板计数(PLT)水平[MD=-9.45,95%CI(-12.60,-6.31),P<0.001]、血浆黏度(PV)水平[MD=-0.29,95%CI(-0.35,-0.24),P<0.001]、大腿周径差[MD=-0.55,95%CI(-0.75,-0.34),P<0.001]、小腿周径差[MD=-0.35,95%CI(-0.47,-0.23),P<0.001];血浆凝血酶原时间(PT)水平[MD=-0.05,95%CI(-1.59,1.50),P=0.95]、血浆部分凝血活酶时间(APTT)水平[MD=-0.22,95%CI(-2.62,2.18),P=0.85]。结论:与单纯西医相比,中西医结合更能有效降低DVT的发生率,提高治疗DVT的效果。
Objective To systematically evaluate the efficacy of integrated traditional Chinese and western medicine in the prevention and treatment of deep vein thrombosis(DVT)in elderly hip fracture patients.Methods The CNKI,Wanfang,VIP,China biomedical literature database,PubMed,EMBASE,Cochrane Library and Web of Science were searched from the establishment of the database to May 17,2021,which collecting all randomized controlled trials(RCT)on the prevention and treatment of deep vein thrombosis in elderly hip fracture patients with integrated traditional Chinese and western medicine(experimental group)compared with western medicine(control group).Two researchers independently screened literatures,extracted data and evaluated the quality according to Cochrane bias risk assessment system.The RevMan 5.4 software was used for metaanalysis.Results A total of 20 articles including 1714 patients were included.Meta analysis results show that the incidence of DVT in integrated traditional Chinese and western medicine group was[RR=0.19,95%CI(0.11,0.32),P<0.001].D-dimer level in integrated traditional Chinese and western medicine group[SMD=-1.59,95%CI(-2.09,-1.09),P<0.001],PLT[MD=-9.45,95%CI(-12.60,-6.31),P<0.001],PV[MD=-0.29,95%CI(-0.35,-0.24),P<0.001],Thigh circumference difference[MD=-0.55,,95%CI(-0.75,-0.34),P<0.001],Leg circumference difference[MD=-0.35,95%CI(-0.47,-0.23),P<0.001].PT[MD=-0.05,95%CI(-1.59,1.50),P=0.95]and APTT[MD=-0.22,95%CI(-2.62,2.18),P=0.85].Conclusion Compared with western medicine alone,integrated traditional Chinese and western medicine can effectively reduce the incidence of DVT and improve the treatment effect of DVT.
作者
李月
常雅茹
郭红玉
于健
曹虹
LI Yue;CHANG Ya-ru;GUO Hong-yu(Tianjin University of Traditional Chinese Medicine,Tianjin(300100),China)
出处
《中国中西医结合外科杂志》
CAS
2022年第3期394-401,共8页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
髋部骨折
深静脉血栓
中西医
META分析
Hip fracture
deep venous thrombosis
integrated traditional Chinese and western medicine
Meta analysis
